甲克霉唑联合超声波臭氧雾化治疗念珠菌性阴道炎疗效观察

Efficacy Observation of A Clotrimazole Combined with Ultrasonic Atomization of Ozone in the Treatment of Candidal Vaginitis

目的:观察甲克霉唑联合超声波臭氧雾化妇科治疗仪治疗女性念珠菌性阴道炎的临床疗效。方法:200例念珠菌性阴道炎患者采取抽签法分为观察组和对照组各100例。对照组给予甲克霉唑乳膏治疗,阴道给药,qd;观察组在对照组治疗基础上加用超声波臭氧雾化妇科治疗仪治疗,qd,15 min/次,共5次。对比两组的临床疗效和6个月复发率,同时治疗前和治疗后第1、第4周行阴道分泌物细菌培养,测定pH。结果:观察组痊愈率和总有效率分别为88%和98%,明显高于对照组的69%和82%(P<0.05)。随访6个月,观察组复发率为1.0%(1/98)明显低于对照组7.3%(6/82)(P<0.05)。治疗后,观察组阴道pH出现明显下降(P<0.05),乳酸杆菌明显增加(P<0.05);而对照组治疗前后p H和菌群数无明显变化(P>0.05)。结论:甲克霉唑加用超声波臭氧雾化妇科治疗仪治疗念珠菌阴道炎能提高治疗效果。

Objective： To observe the efficacy of A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis. Methods： Totally 200 cases of candidal vaginitis were divided into the observation group and the control group with100 cases in each. The control group was given A clotrimazole creams through vaginal administration,qd,while the observation group was treated by ultrasonic atomization of ozone additionally,qd,15 min per time with five times. The clinical efficacy and the recurrence rate after 6 months of the two groups were compared. Before the treatment and in the first and fourth week after the treatment,vaginal secretion bacterial culture was performed and p H value was detected. Results： The cure rate and the total effective rate of the observation group was 88% and 98%,respectively,which was significantly higher than that of the control group（ 69% and 82%,respectively,P〈0. 05）. After the 6-month follow-up,the recurrence rate was 1. 0% in the observation group（ 1 /98）,which was significantly lower than that in the control group [7. 3%（ 6 /82）,P〈0. 05]. After the treatment,the vaginal p H value in the observation group was reduced notably and the number of lactobacillus was increased significantly（ P〈0. 05）,while those in the control group were without significant changes（ P〉0. 05）. Conclusion： A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis can improve the therapeutic effect.