胃溃疡患者牙周基础治疗对胃幽门螺杆菌根除率影响

Effect of Initial Periodontal Therapy on Eradiation Rate of Gastric Helicobacter Pylori in Patients with Gastric Ulcer

目的:观察胃溃疡患者给予牙周基础治疗后胃内幽门螺杆菌(Hp)清除率变化,探讨牙周基础治疗对胃溃疡治疗的辅助效果;方法:胃溃疡病伴有牙周疾病的患者88例随机分为2组,对照组44例给予常规三联药物治疗,观察组44例在对照组基础上再给予牙周基础治疗,疗程1个月。治疗后1,3,6,12个月,检测牙周及胃内Hp变化,比较两组Hp根除率。结果:治疗后3,6,12个月,观察组Hp根除率均显著高于对照组(P<0.05)。结论:对于有牙周疾患的胃溃疡Hp感染患者,在三联治疗的基础上辅助牙周基础治疗,能明显提高Hp根除率。

Objective： To investigate the adjuvant effect of initial periodontal therapy by observing the eradiation rate of gastric helicobacter pylori（ Hp） in the patients with gastric ulcer treated by the therapy. Methods： Totally 88 patients with stomach ulcer and chronic periodontitis were enrolled and randomly divided into two groups. The control group was treated by triple therapy,the experimental group was treated by initial periodontal therapy additionally with the treatment course of one month. The changes of Hp in stomach and periodontium were observed and the eradiation rate of Hp was compared between the two groups respectively after 1-,3-,6- and 12-month treatment. Results： After 3,6 and 12 months,the eradiation rate in the experimental group was significantly higher than that in the other group（ P〈0. 05）. Conclusion： Initial periodontal therapy combined with triple therapy can obviously improve the eradication rate of gastric Hp in the patients with gastric ulcer and chronic periodontitis.