摘要
目的：应用近红外漫反射光谱技术建立盐酸坦洛新缓释胶囊的一致性检验模型。方法：在4 200-12 000 cm-1范围内对盐酸坦洛新缓释胶囊进行扫描,建立一致性检验模型。结果：选用9 000-7 500 cm-1、6 900-5 600 cm-1、5 000-4250 cm-1谱段,用二阶导数＋失量归一化进行处理,确定CI值为7,使用一致性检验模型可区分正品和伪品盐酸坦洛新缓释胶囊。结论：该方法操作简单、灵敏、准确、快速,可用于盐酸坦洛新缓释胶囊真伪的鉴别。
Objective： To establish the conformity test model for tamsulosin hydrochloride sustained-release capsules by near infrared absorption spectroscopy. Methods： Tamsulosin hydrochloride sustained release capsules were scanned within the range of4 200-12000 cm^-1 to establish the conformity test model. Results： The spectral coverage of 9 000-7 500 cm^-1,6 900-5 600 cm^-1 and 5 000-4 250 cm^-1 were chosen,and the second derivative vector normalization was used to detect the samples. The CI value was 7.The conformity test model could distinguish authentic and false tamsulosin hydrochloride sustained-release capsules. Conclusion：The method is simple, sensitive, accurate and fast, and can be used in the identification of tamsulosin hydrochloride sustained-release capsules.
出处
《中国药师》
CAS
2014年第12期2138-2139,2142,共3页
China Pharmacist
关键词
盐酸坦洛新缓释胶囊
近红外光谱
一致性检验
Tamsulosin hydrochloride sustained-release capsules
NIR
Conformity test
