围手术期负荷剂量他汀对急性ST段抬高型心肌梗死患者预后的影响

Influence of Peri-operation Period of Loading Dose Atorvastatin on the Prognosis of Patients with Acute ST Segment Elevation Myocardial Infarction

为了探讨围手术期给予阿托伐他汀负荷剂量对急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)后对心血管事件的影响。选取因STEMI行急诊PCI术患者160例,其中80例于PCI术前给予阿托伐他汀负荷剂量40mg,80例术前未给予阿托伐他汀负荷剂量进行研究。分析两组患者住院期间肌酸激酶同工酶与超敏C反应蛋白值,PCI术后与术后1个月心功能情况。结果显示围手术期阿托伐他汀负荷剂量组主要心血管事件发生率优于非阿托伐他汀组(P<0.05)。因此,围手术期给予负荷剂量的阿托伐他汀可以降低住院期间不良心血管事件的发生率,改善患者预后。

To analysis the effects on cardiovascular events and cardiac function that are given atorvastatin loading dose in acute ST segment elevation myocardial infarction （STEMI） undergoing emergency percutaneous coronary intervention （PCI） during peri-operation period, we selected 160 patients with STEMI underwent emergency PCI operation from 2012 January to 2014 January in Department of Cardiology, the First Affiliated Hospital of Liaoning Medical University from including 80 cases of PCI patients in the preoperative administration of atorvastatin loading dose of 40rag, the other 80 patients were not given a loading dose of atorvastatin. We analysed the CK-MB,CPR postoperative cardiac function, in patients of the two groups. The incidence of cardiovascular events is better in loading dose atorvastatin group than no atorvastatin group （P〈0.05）. Therefore, a loading dose of atorvastatin that are given during peri-operation can reduce the incidence of adverse cardiovascular events, improve the prognosis of the patients.