中医药调控肿瘤微环境的研究进展

Study Progress on Chinese Medicine Regulation of Tumor Microenvironment

肿瘤微环境的变化是造成肿瘤恶化、转移、复发的重要因素。针对肿瘤微环境中的低氧、低p H、间质高压、生长因子等因素对其调控,可在一定程度上、克服免疫耐受、促进肿瘤内部血管正常化、抑制肿瘤干细胞的增殖与分化,从而提高疗效。因此,从肿瘤微环境的角度出发,运用中医药对肿瘤的微环境进行整体调控,可能会为探寻治疗肿瘤的方法提供一条新的途径。

The change of the tumor microenvironment is one of important factors that cause the aggravation,metastasis,and recurrence of the tumor.By controlling some of the factors such as the oxygen deficiency,the acid environment,interstitial cell voltage and some growth factors can overcome the immune tolerance,promote vascular normalization,and inhibit the proliferation and differentiation of tumor.Therefore,using Chinese herbsmechanisms of anti-tumor to change the tumor microenvironment will open up a brand new field for tumor treatment.