ALDH1在OLP和LK组织中的表达及其意义

The role of ALDH1 in oral leukoplakia and oral lichen planus

目的:通过检测干细胞标记物ALDH1在口腔扁平苔藓(OLP)和白斑(LK)中的表达水平,评价其与癌变的关系。方法:采用免疫组织化学SP法检测ALDH1在10例正常口腔黏膜,30例OLP,60例LK,10例口腔鳞癌(OSCC)中表达水平;再检测ALDH1在30例癌变与30例未癌变LK中的表达差异。结果:ALDH1在正常口腔黏膜中不表达,在OLP、LK和OSCC中的表达率分别为26.7%,63.3%和90.0%(P<0.05);ALDH1在未癌变和癌变LK中的表达率分别是43.3%和83.3%(P<0.01)。结论:ALDH1与口腔黏膜恶性潜能程度相关,可能是预测癌变的分子标记物。

Objective：To investgate the role of stem cell marker ALDH1 in oral carcinogenesis process. Method：ALDH1 expression in 10 cases of normal oral mucosa,30 cases of oral lichen planus,60 cases of oral leukoplakia,10 cases of oral squamous cell carcinoma was detected by immunohistochemistry. And the difference of ALDH1 expression in 30 cas-es of untransformed leukoplakia and 30 cases of malignant-transformed leukoplakia was detected. Result：ALDH1 was not found in normal oral mucosa,and it was found in 26.7 %,63.3%and 90.0%of oral lichen planus,oral leukoplakia and o-ral squamous cell carcinoma,respectively （P 〈0.05）;ALDH1 expression rate in untransformed leukoplakia and transformed leukoplakia was 43.3 % and 83.3 %（P 〈0.01）. Conclusion：ALDH1 correlated with malignant potential of oral mucosa, and it may be a marker of malignant transformation.