子宫内膜异位症患者血清CA_(125)、HE4、EMAb的表达及其临床意义

Clinical Significance of Levels of CA_(125)、HE4、EMAb for Diagnosis in Endometriosis

目的：探讨血清癌抗原125（CA125）、人附睾分泌蛋白4（HE4）、抗子宫内膜抗体（EMAb）在子宫内膜异位症（EMT）中的表达及其临床意义.方法：选择2007年1月至2013年12月沂水中心医院收治的EMT患者60例为观察组,同期体检健康者53例为对照组.于治疗前检测CA125、HE4、EMAb水平,并计算敏感度、特异度.结果：观察组的血清CA125、HE4、EMAb水平均高于对照组,P＜0.05.观察组中血清CA125、HE4水平在Ⅲ～Ⅳ期患者均高于Ⅰ～Ⅱ期患者（P＜0.05）,而血清中EMAb在Ⅲ～Ⅳ期患者虽略高于Ⅰ～Ⅱ期患者,但差异无统计学意义（P＞0.05）.联合检测3项指标时,诊断EMT的敏感度、特异度,均高于单独检测血清CA 125、HE4、EMAb的敏感度、特异度,差异均有统计学意义（P＜0.05）.结论：EMT患者血清CA125、HE4及EMAb水平明显升高,且随着期别的升高血清CA125、HE4的表达水平逐渐增强.联合检测3项指标可明显提高诊断EMT的敏感度、特异度,提示联合检测3项指标对于诊断EMT有较高的价值.

Objective：To explore the expressions of cancer antigen125 （CA125）, human epididymis protein 4 （HE4） and anti-endometrial antibody（EMAb） and their the clinical value for diagnosis in endometriosis. Methods： 60 patients with EMT in the Yishui Central Hospital of Linyi city from January 2007 to December 2013 were selected as observation group,53 healthy volunteers were chosen as control group. CA125.HE4,EMAb were detected and compared before the treatment and the sensitivity and specificity were calculated respectively. Results：The concentration of serum CA125, HE4, EMAb in the observation group were higher than those in control group, P 〈 0. 05;The concentration of serum CA125, HE4 in patients with endometriosis stage Ⅲ -Ⅳ were higher than those in stage Ⅰ - Ⅱ ,P 〈 0. 05 ; Although , the serum levels of EMAb in patients with stage Ⅲ -Ⅳ was slightly higher than that in stage Ⅰ - Ⅱ ,without significant difference, P 〉0.05. In combined detection,the sensitivity,specificity were higher than those in alone detection of serum CA12s, HE4 and EMAb, and the difference had statistical significance, P 〈 0.05. Conclusions ：The concentration of serum CA125, HE4, EMAb of the patients with en- dometriosis increase significantly;combined detection of the three indexes which can improve the sensitivity and specificity,has high value for the diagnosis of endometriosis.