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表皮生长因子受体在恶性胶质瘤诊治中的研究进展 被引量：4

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摘要 胶质瘤是常见的原发性脑肿瘤,约占颅内肿瘤的35％ ～45％,其中恶性胶质瘤预后差,致残率高.尽管目前的标准治疗方案—手术联合放疗和替莫唑胺化疗能将胶质母细胞瘤（glioblastoma,GBM）的平均生存期提高至14.6个月,但总体预后仍远远落后于其他肿瘤1.而在胶质瘤的发展过程中伴随着许多基因学和表观遗传学水平的变化,这些一系列的改变可影响肿瘤细胞的生物学行为,同样也使得针对这些改变来治疗胶质瘤成为可能.近年由于分子生物学的蓬勃发展,分子靶向药物在各类肿瘤有了重大进展.表皮生长因子受体（epidermal growth factor receptor,EGFR）是原癌基因C-erb-B1的表达产物,不仅在人体正常细胞,在许多恶性肿瘤有高表达,而表皮生长因子突变体Ⅲ（epidermal growth factor receptor typeⅢvariant,EGFRvⅢ）则仅在恶性肿瘤中有表达.
作者 郭子睿 毛颖
机构地区 复旦大学附属华山医院神经外科
出处 《中华神经外科杂志》 CSCD 北大核心 2014年第11期1183-1185,共3页 Chinese Journal of Neurosurgery
关键词 表皮生长因子受体 恶性胶质瘤 receptor 原发性脑肿瘤 标准治疗方案 诊治 胶质母细胞瘤 分子靶向药物
分类号 R739.41 [医药卫生—肿瘤]
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参考文献27

  • 1Stupp R,Mason WP,van den Bent M J,et al.Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma[J].N Engl J Med,2005,352:987-996.
  • 2Cameron W,Brennan B,Roel GW,et al.The somatic genomic landscape of glioblastoma[J].Cell,2013,155:462-477.
  • 3Ekstrand AJ,James CD,Cavenee WK,et al.Genes for epidermal growth factor receptor,transforming growth factor alpha,and epidermal growth factor and their expression in human gliomas in vivo[J].Cancer Res,1991,51:2164-2172.
  • 4蔡秀梅,王丽影,查锡良.PTEN下调FAK磷酸化来抑制EGFR受体突变体引起的胶质瘤细胞侵袭[J].中国癌症杂志,2008,18(1):30-34. 被引量：6
  • 5Yin S,Van Meir EG.p53 pathway alterations in brain tumors.In:Van Meir EG,ed.CNS Cancer:Models,Markers,Prognostic Factors,Targets and Therapeutic Approaches[M].New York:Humana Press (Springer),2009:283-314.
  • 6Pedersen MW,Meltom M,Damstrup L,et al.The type Ⅲ epidermal growth factor receptor mutation-Biological significance and potential target for anti-cancer therapy[J].Ann Oncol,2001,12:745-760.
  • 7Tanaka K,Babic I,Nathanson D,et al.Oncogenic EGFR signaling activates an mTORC2-NF-kB pathway that promotes chemotherapy resistance[J].Cancer Discov,2011,1:524-538.
  • 8Cvrljevic AN,Akhavan D,Wu M,et al.Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRv Ⅲ) in glioma cells:implications for glucose metabolism[J].J Cell Sci,2011,124:2938-2950.
  • 9Feng H,Jarzynka MJ,Keezer S,et al.Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRv Ⅲ-driven glioblastoma tumorigenesis[J].Proc Natl Acad Sci,2012,109:3018-3023.
  • 10Gelareh Z,Krishna PL,Kenneth A,et al.EGFR and EGFRv Ⅲ in glioblastoma:partners in crime[J].Cancer Cell,2013,24:403-404.

二级参考文献28

  • 1Wong AJ, Bigner SH, Bigner DD, et at. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification [ J ]. Proc Natl Acad Sci USA, 1987, 84(19) : 6899-6905.
  • 2Garcia de Palazzo IE, Adams GP, Sundareshan P. Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas[J]. Cancer Res, 1993, 53(14) : 3217-3220.
  • 3Moscatello DK, Holgado-Madruga M, Godwin AK. Frequent expression of mutant epidermal growth factor receptor in multiple human tumors[ J ]. Cancer Res, 1995,55 (23) :5536-5539.
  • 4Damstrup L, Wandahl PM, Bastholm L, et al. Epidermal growth factor receptor mutation type Ⅲ transfected into a small cell lung cancer cell line is predominantly localized at the cell surface and enhances the malignant phenotype [J]. Int J Cancer, 2002, 97(1): 7-14.
  • 5Moscatello D, Montgomery R, Sundareshan P, et al. Transformational and altered siganl transduction by a maturally coccurring mutant EGF receptor[ J ]. Oncogene, 1996,13 ( 1 ) :85-96.
  • 6Nagane M, Coufal F, Lin H. A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human gliobastoma cells by increasing proliferation and reducing apoptosis[J]. Cancer Res, 1996, 56(21 ) : 5079-5086.
  • 7Huang HS, Nagane M, Klingbeil CK, et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling [ J ]. J Biol Chem,1997, 272(5) : 2927-2935.
  • 8Lal A, Glazer CA, Martinson HM, et al. Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion [J]. Cancer Res, 2002, 62( 12): 3335-3339.
  • 9Pedersen MW, Tkach V, Pedersen N, et al. Expression of a naturally occurring constitutively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility [ J ]. Int J Cancer, 2004, 108(5) : 643-653.
  • 10Ge H, Gong X, Tang CK. Evidence of high incidence of EGFRv Ⅲ expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis[ J ]. Int J Cancer, 2002, 98 ( 3 ) : 357-361.

共引文献28

同被引文献29

引证文献4

二级引证文献5

中华神经外科杂志
2014年 第11期

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