侵袭性牙周炎患者血浆钙结合蛋白与血液中性粒细胞数相关性的研究

The correlation between plasma calprotectin and neutrophil count in patients with aggressive periodontitis

目的 比较侵袭性牙周炎患者血浆钙结合蛋白水平的变化及与血液中性粒细胞的相关关系,探讨钙结合蛋白在侵袭性牙周炎发生发展中的作用.方法 抽取61例侵袭性牙周炎患者（侵袭性牙周炎组）和48名牙周健康者（健康对照组）的空腹静脉血,采用酶联免疫吸附测定法检测血浆中钙结合蛋白水平,比较两组的差异,并分析血浆钙结合蛋白与各项牙周临床参数和血细胞计数之间的相关关系.结果 侵袭性牙周炎组血浆钙结合蛋白质量浓度为（2.1±1.1） mg/L,显著高于健康对照组[（1.5±0.6）mg/L],P＜0.01.血浆钙结合蛋白与出血指数（r=0.271,P=0.035）、探诊深度（r=0.437,P=0.000）、附着丧失（r=0.450,P=0.000）和重度位点百分比（r=0.423,P=0.001）均呈显著的正相关关系,中性粒细胞数与血浆钙结合蛋白之间也呈显著正相关关系（r=0.380,P=0.004）.结论 侵袭性牙周炎可能与血浆钙结合蛋白的水平升高有关.

Objective To measure the levels of plasma calprotectin in aggressive periodontitis （AgP） patients and to analyze the relationship between the plasma calprotectin and neutrophil count.Methods Venous blood samples were collected from 61 AgP patients and 48 periodontally healthy controls.Clinical examination consisted of bleeding index（BI）,probing depth（PD）,attachment loss measurements（AL） and percentage of severe sites.Plasma level of calprotectin was determined by enzyme-linked immunosorbent assay.Results The plasma concentrations of calprotectin in AgP patients [（2.1 ± 1.1） mg/L] were significantly higher than those in healthy controls[（1.5 ± 0.6） mg/L] （P＜0.01）.The plasma concentration of calprotectin in AgP patients was positively correlated with BI （r=0.271,P=0.035）,PD（r=0.437,P=0.000）,AL（r=0.450,P=0.000） and percentage of severe sites（r=0.423,P=0.001）.While the neutrophil count was also positively correlated with the plasma concentrations of calprotectin in AgP patients （r=0.380,P=0.004）.Conclusions AgP may have impact on the elevation of plasma level of calprotectin.