感染性休克患者早期血降钙素原及纤维蛋白原变化的临床意义

Clinical significance of the changes of early serum procalcitonin and fibrinogen in patients with septic shock

目的探讨感染性休克患者早期血降钙素原及纤维蛋白原的表达水平及其临床意义。方法选取于我院2013年1-12月收治40例感染性休克患者,同时选取同期于我院住院的40例非感染性休克者为对照组,分别于治疗前及治疗后第1、3、5天采取静脉血分别检测降钙素原、纤维蛋白原的变化。结果与对照组比较,感染性休克治疗前及治疗后第1、3、5天患者血降钙素原及纤维蛋白原水平明显升高（P〈0.05）,治疗后感染性休克组治疗后第1、3天逐渐升高,于治疗后第3天达到高峰后逐渐下降,治疗后第5天血降钙素原及纤维蛋白原水平明显低于第3天（P〈0.05）。结论早期联合监测血降钙素原及纤维蛋白原的变化有助于判断感染性休克患者病情严重程度。

Objective To study the expression level and clinical significance of early serum procalcitonin and fibrinogen in patients with septic shock. Methods To select 40 patients with septic shock as septic shock group and 40 patients without septic shock as control group in our hospital from January 2013 to December 2013.To respectively detect the changes of procalcitonin and fibrinogen of venous blood before treatment and after treatment in the 1st,3rd,5th days. Results The expression level of serum procalcitonin and fibrinogen were significantly increased in septic shock group compared with control group before treatment and after treatment in the 1st,3rd,5th days（P〈0.05）.In septic shock group,which were increased gradually after treatment in the 1st day and the 3rd days and then decreased gradually after reaching a peak in the 3rd days,were significantly lower in the 5th days compared with the 3rd days（P 0.05）. Conclusion Early combinative monitoring of the changes of serum procalcitonin and fibrinogen is helpful to diagnosis the disease severity of patients with septic shock.