六味地黄汤加减治疗2型糖尿病肾病Ⅳ期79例疗效观察

Clinical effects observation of Liuwei Dihuang Decoction in treatment of 79 patients with diabetic nephropathy

目的探讨中西医结合治疗2型糖尿病肾病Ⅳ期的治疗效果。方法选择2010年01月-2013年12月我院住院治疗的2型糖尿病肾病Ⅳ期患者158例,采用重组人胰岛素、依那普利和/或氯沙坦、胰激肽原酶、阿托伐汀钙等治疗79例作为西医治疗组,在西医治疗基础上加服六味地黄汤加减79例作为中西医结合治疗组。两组持续治疗2个月。观察并比较两组治疗前后24h尿蛋白定量的变化及生化指标变化。结果西医治疗组总有效率为83.54%,中西医结合治疗组的总有效率为91.14%,两组相比,差异有统计学意义（P〈0.05）,中西医结合组24h尿蛋白定量降低和血黏度改善优于西医组（P〈0.05）。结论中西医结合治疗2型糖尿病肾病Ⅳ期的治疗效果显著,能有效延缓2型糖尿病肾病Ⅳ期进展。

Objective To investigate the Clinical effects of traditional Chinese and western medicine in treatment of diabetic nephropathy. Methods 158 patients with diabetic nephropathy from the 2010 January to 2013 December in our hospital were divided into the western medicine group and the cooperation of chinese and western medicine treatment group,79 cases in each group. The western medicine group was given the treatment of recombinant human insulin,bea Knapp Leigh and/or losartan,pancreatic kininogenase,atorvastatin calcium,etc. On the basis of western medicine,the cooperation of chinese and western medicine treatment group was give Liuwei Dihuang Decoction. The treatments of two groups were continued for 2 months. The urinary protein quantitative change and biochemical indexes change in 24 hour were observed and compared between before and after treatment in both groups. Results The total effectiveness of western medicine treatment group was 83.54%,and the total efficiency of the combine traditional Chinese and Western medicine treatment group was 91.14%. The difference of two groups was statistically significant（P〈0.05）. 24 hour urinary protein quantitative and reduce blood viscosity of the combine traditional Chinese and Western medicine treatment group were better than those of the control group（P〈0.05）. Conclusion Combine traditional Chinese and Western medicine treatment of diabetic nephropathy is obvious curative effect,can effectively delay the progression of diabetic nephropathy.