血浆游离DNA的甲基化与食管癌的关系

DNA methylation in plasma and esophageal cancer

DNA甲基化是影响表观遗传的重要机制之一,其在基因表观遗传调控中起重要作用.研究表明,DNA甲基化在食管癌的发生发展中起重要作用,食管癌患者血浆和癌组织中基因甲基化水平具有良好一致性,血浆是研究甲基化的可靠资源.血浆DNA启动子异常甲基化的检测对食管癌的早期诊断、病情和治疗效果的监测、预后评估等具有良好的应用价值.

DNA methylation is one of the important epi~ genetic mechanisms, playing an important role in epigenetic gene regulation. Studies have shown that DNA methylation has an impor- tant role in the occurrence and development of esophageal cancer. The levels of gene meth- ylation in plasma and tissues in patients with esophageal cancer have a good consistency, so plasma is a reliable resource for the study of methylation. The detection of DNA hypermeth- ylation in plasma has good value for early diag~ nosis and monitoring of therapeutic effect and prognosis of esophageal cancer.