轻度胃肠炎伴婴幼儿良性惊厥患儿血清硫化氢水平变化的研究

Serum hydrogen sulfide levels in children with benign infantile convulsions associated with mild gastroenteritis

目的研究轻度胃肠炎伴婴幼儿良性惊厥(BICE)患儿血清硫化氢(H2S)水平的变化及意义。方法选择住院治疗的42例BICE患儿为观察组,同期因单纯急性胃肠炎入院治疗的46例患儿为对照组。使用分光光度计法检测其血清H2S水平。结果观察组患儿血清H2S水平显著低于对照组(28±12μmol/L vs45±10μmol/L,P<0.O1)。惊厥发作次数≥2次患儿血清H2S水平显著低于发作次数<2次患儿(P<0.O5)。BICE患儿惊厥发作次数与血清H2S水平呈负相关(r=-0.485,P=0.001);惊厥持续时间≥5 min组患儿的发作时间与血清H2S水平呈负相关(r=-0.736,P=0.004)。结论内源性H2S水平的降低可能是BICE患儿发病原因之一;血清H2S水平下降程度与惊厥发生的次数及发作超过5 min的持续时间有关,其临床意义有待于更多的研究证实。

Objective To study the changes and signiifcance of serum hydrogen sulifde （H2S） levels in children with benign infantile convulsions associated with mild gastroenteritis （BICE）. Methods Forty-two hospitalized children diagnosed with BICE were recruited to the observation group, and 46 children admitted due to acute gastroenteritis alone were recruited to the control group. Serum H2S levels were measured by a spectrophotometer. Results The serum H2S level in the observation group was signiifcantly lower than in the control group （28±12μmol/L vs 45±10μmol/L;P〈0.01）. The patients with a number of convulsions greater than or equal to two had signiifcantly lower serum H2S levels than those with a number less than two （P〈0.05）. The number of convulsions was negatively correlated with serum H2S level in BICE patients （r=-0.485, P=0.001）. When a convulsion exceeded 5 minues in duration, the duration was negatively correlated with serum H2S level （r=-0.736, P=0.004）. Conclusions The reduction in endogenous H2S level might be one of the causes of convulsions in BICE patients. The degree of reduction in H2S level is associated with the number of convulsions and the duration of convulsion （when it exceeds 5 minues）. Further investigation is needed to determine the clinical signiifcance of these results.