新生儿生后血清神经元特异性烯醇化酶浓度的动态变化

Dynamic changes in serum neuron-specific enolase levels in neonates

目的了解新生儿生后血清神经元特异性烯醇化酶(NSE)的浓度变化。方法选取无窒息史、无神经系统疾病史的20例足月儿及同期出生的30例早产儿作为研究对象。30例早产儿中,晚期早产儿和早期早产儿各15例。应用电化学发光法测定新生儿生后第1、3、7天血清NSE浓度。10例正常成人作为对照组。结果足月儿组与两个早产儿组出生后血清NSE含量均随日龄增加而逐渐降低(P<0.01)。足月儿组与两个早产儿组生后第1、3、7天血清NSE含量均高于正常成人组,差异有统计学意义(P<0.01)。生后第1、3、7天早期早产儿组血清NSE含量高于足月儿组,差异有统计学意义(P<0.01)。结论新生儿生后早期血清NSE含量高于成人正常参考值,且与出生胎龄与日龄有关,故应根据胎龄与日龄确定新生儿血清NSE的参考值,不应以成人指标界定其值正常与否。

Objective To determine the postnatal changes in serum neuron-specific enolase （NSE） level in neonates. Methods Twenty full-term infants and 30 preterm infants without a history of asphyxia or neurological disease born over the same period were enrolled. The 30 preterm infants consisted of 15 late preterm births and 15 early preterm births. Serum NSE levels were determined using electrochemical immunosensor array on postnatal days 1, 3 and 7. Ten healthy adults volunteered as controls. Results Serum NSE levels in neonates of the full-term group and two preterm groups gradually decreased with increasing birth age （P〈0.01）. All the three groups of neonates had signiifcantly higher serum NSE levels on postnatal days 1, 3, and 7 than the healthy adult group （P〈0.01）. The early preterm group had signiifcantly higher serum NSE levels than the full-term group on postnatal days 1, 3, and 7 （P〈0.01）. Conclusions Serum NSE level in neonates during early postnatal days is related to gestational and birth ages and higher than the normal adult level. The reference value for normal serum NSE level in neonates should be determined according to gestational and birth ages, rather than the normal adult level.