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长链非编码RNA研究进展 被引量:11

Advances of Long Noncoding RNA
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摘要 长链非编码RNA(long noncoding RNAs,lncRNAs)是一类长度超过200nt的非编码RNA分子,通过信号分子、诱饵分子、引导分子、支架分子等4种方式在转录水平和转录后水平调控基因的表达。lncRNAs的表达水平相对于蛋白编码基因较低,但它们在X染色体沉默、基因组印迹、染色体修饰、转录激活、转录干扰以及核内运输等方面具有重要的功能。相对于研究较多的非编码小RNA,lncRNAs的功能目前尚不完全清楚。该文从lncRNAs的起源、分类、分子机制、功能和进化等方面综述了lncRNAs的研究进展,为进一步探究lncRNAs的功能和作用机制提供依据。 Long noncoding RNAs(lncRNAs)are noncoding RNAs longer than 200 nucleotides,they can regulate gene expression at transcription and post-transcription level as signals,decoys,guides,and scaffolds.Compared to the expression of protein-coding genes,expression of lncRNAs is lower,but they have important function in X chromosome silencing,genomic imprinting,chromosome modification,transcription activation,transcription interference and nuclear transport.In comparison to small noncoding RNAs,the function of lncRNAs is largely unclear.Advance are highlighted according to origin,classification,molecular mechanism,function and evolution of long noncoding RNAs,which providing aguide for further study of function and molecular mechanism of lncRNAs.
出处 《西北植物学报》 CAS CSCD 北大核心 2014年第11期2357-2365,共9页 Acta Botanica Boreali-Occidentalia Sinica
基金 国家自然科学基金(31070256) 陕西师范大学研究生培养创新基金(2013CXS020)
关键词 长链非编码RNA 分子机制 功能 进化 long noncoding RNAs molecular mechanism function evolution
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参考文献55

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共引文献33

同被引文献88

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