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精浆对胚胎着床的影响

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摘要 体外受精-胚胎移植(IVF-ET)的种植率和妊娠率始终低于自然妊娠,宫腔内无精液的作用是其与自然妊娠过程的不同点之一。精浆具有免疫活性,暴露于精浆可以引起母体对胚胎的免疫耐受,有助于胚胎的种植和发育。其机制可能是精浆内存在潜在的免疫调节物质,主要是转化生长因子-β(TGFβ)和前列腺素E(PGE)家族成员,通过诱导和消退炎性反应及抗原呈递细胞和淋巴细胞的表型偏斜,上调Th2型细胞因子,提高围着床期子宫内膜的容受性,以利于胚胎的植入和妊娠的维持。
作者 王瑞玲 石红 张慧
机构地区 武汉市武昌医院妇产科 大连医科大学附属第一医院妇产科
出处 《中国妇产科临床杂志》 2014年第6期566-568,共3页 Chinese Journal of Clinical Obstetrics and Gynecology
关键词 体外受精-胚胎移植 精浆 胚胎着床
分类号 R714.8 [医药卫生—妇产科学]
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参考文献23

  • 1Flowers WL, Esbenshade KL. Optimizing management of natural and artificial mateings in swine. J Reprod Fertil, 1993, 48; 217-228.
  • 2Carp H, Serr D, Mashiach S. Influence of insemination on the implantation of transfered rat blastocysts. Gynecol Oh- stet Invest, 1984, 18: 194-198.
  • 3王瑞玲,石红,张慧.小鼠精浆对子宫内膜容受性和胚胎着床的影响[J].中国计划生育学杂志,2013,21(8):518-523. 被引量：5
  • 4Bellinge BS, Copeland CM, Thomas TD, et al. The influ- ence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer program. Fertil Steril, 1986, 46: 252-256.
  • 5Tremellen KP, Valbuena D, Landeras J, et al. The effect of intercourse on pregnancy rates during assisted human repro- duction. Hum Reprod, 2000, 15:2653 - 2658.
  • 6Nancy P, Tagliani E, Tay CS, et al. Chemokine gene silen cing in decidual stromal cells limits T cell access to the mater- nal- fetal interface. Science, 2012, 336:1317 - 1321.
  • 7Kwak - Kim JY, Chung - Bang HS, Ng SC, et al. Increased thelper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and infertile women with multiple implantation failures after IVF. Hum Reprod, 2003, 18: 767-773.
  • 8O'Leary S, Armstrong DT, Robertson SA. Transforming growth factor - β (TGF -β) in porcine seminal plasma. Re- prod Fertil Dev, 2011, 23: 748- 758.
  • 9Robertoson SA, Guerin LR, Bromfield KM, et al. Seminal fluid drives expansion of the CD4+ CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice.Biol Reprod, 2009, 80:1036- 1045.
  • 10Huang SJ, Zenclussen AC, Chen CP, et al. The implication of aberrant GM - CSF expression in decidual cells in the patho gene sis of preeclapsieu Am J Pathol, 2010, 177: 2472- 2482.

二级参考文献31

  • 1Perrier DS, Charlet-Renard C, Goffin F, et al. The implantation window[J].J Gynecol Obstet Biol Reprod, 2002, 31 (5) :440-455.
  • 2Tremellen KP,Valbuena D, Landeras J, et al. The effect of intercourse on pregnancy rates during assisted human reproduction[J]. Hum Reprod, 2000,15(12) :2653-2658.
  • 3Robertson SA, Sharkey DJ. The role of semen in induction of maternal immune tolerance to pregnancy[J]. Semin Immunol, 2001, 13(4):243-254.
  • 4Coulam CB, Stern JJ. Effect of seminal plasma on implantation rates[J]. Early pregnancy, 1995,1(1): 33-36.
  • 5Gutsche S, von Wolff M, Strowitzki T, et al. Seminal plasma induced mRNA expression of IL-1β,IL-6 and LIF in endometrial epithelial cells in vitro[J].Mol Hum Reprod,2003,9(12):785 -791.
  • 6Joo BS, Kim MK, Na YJ. The mechanism of action of coculture on embryo development in the mouse model: direct embryo-to-cell contact and the removal of deleterious components[J].Fertil Steril, 2001, 75(1): 193-199.
  • 7Akoum A, Jolicoeur C, Boucher A. Estradiol amplifies interleukin 1-induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis[J].J Clin Endocrinol Metab, 2000,85(2):896-904.
  • 8Flowers WL, Esbenshade KL. Optimizing management of natural and artificial matings in swine[J]. J Reprod Fertil, 1993,48(Suppl) : 217-228.
  • 9Bellinge BS, Copeland CM, Thomas TD, et al. The influence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer program[J]. Fertil Steril, 1986,46(2) :252-256.
  • 10Jiang HY, WSO, Lee KH, et al. Ablation of paternal acces sory sex glands is detrimental to embryo development during implantation[J]. Anat Embryo, 2001,203 (4) : 255-263.

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中国妇产科临床杂志
2014年 第6期

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