摘要
整合素相互作用蛋白Kindlin是一种新型的黏着斑蛋白,是进化上高度保守的含有FERM结构域的蛋白家族,目前已知有3个家族成员Kindlin-1、Kindlin-2和Kindlin-3。近年来研究表明,Kindlin家族不仅与整合素活化和多种遗传性疾病有关,而且作为重要的信号分子参与了肿瘤的发生发展过程。我们将从Kindlin的结构特征、组织分布及生物学功能的研究进展作一综述。
Integrin-interaeting protein kindlin is a novel family of focal adhesion proteins consisting of three members, Kindlin-1, Kindlln-2 and Kindlin-3. Kindlins are highly conserved and belong to FERM-eontaining proteins. Present studies have showed there is a close relationship between Kindlin family and integrin activation and genetic diseases. In addition, Kindlin family is also a critical mediator for tumorigenesis. We review structural features, distribution and progress of biological functions of kindlin family in this paper.
出处
《解剖学报》
CAS
CSCD
北大核心
2014年第6期865-869,共5页
Acta Anatomica Sinica
基金
国家自然科学基金资助项目(31170711)
