肝细胞癌手术后辅助肝动脉化疗栓塞与单纯手术的疗效比较

Efficacy of surgery combined with postoperative hepatic arterial chemoembolization vs surgery alone in patients with hepatocellular carcinoma

目的:探讨临床中肝细胞癌手术后辅助肝动脉化疗栓塞(transcatheter arterial chemoembolization)的临床效果,并与单纯手术进行对比观察.方法:采取回顾性方法对2010-01/2011-06南阳市中心医院肝脏普外120例肝细胞癌手术患者的临床资料进行分析,术后辅以肝动脉化疗栓塞的50例患者为研究组,单纯手术的70例患者为对照组,观察两组的临床治疗效果.结果:研究组术后1年、2年和3年生存率为84.0%、62.0%、40.0%vs对照组的70.0%、41.4%、21.4%,有统计学意义(P<0.05);研究组术后1、2和3年复发率为10.0%、14.0%、26.0%vs对照组的20.0%、30.0%、37.1%,有统计学意义(P<0.05).结论:临床中肝细胞癌手术患者术后辅以肝动脉化疗栓塞治疗是可行的,能够提高患者的生存率,降低复发率,值得临床中应用与推广.

AIM： To compare the efficacy of surgery combined with postoperative hepatic arterial chemoembolization vs surgery alone in the treatment of hepatocellular carcinoma. METHODS： Clinical data for 120 patients with hepatocellular carcinoma who underwent surgery at Nanyang Central Hospital from January 2010 to June 2011 were analyzed ret-, rospectively. Of all patients, 50 underwent surgery plus postoperative hepatic arterial chemoembolization（study group） and 70 underwent surgery alone（control group）. Clinical effects were compared between the two groups. RESULTS： The 1-, 2- and 3-year survival rates were significantly higher in the study group than in the control group（84.0% vs 70.0%, 62.0% vs 41.4%, 40.0% vs 21.4%, P〈0.05）. The 1-, 2- and 3-year recurrence rates were significantly lower in the study group than in the control group（10.0% vs 20.0%, 14.0% vs 30.0%, 26.0% vs 37.1%, P〈0.05）.CONCLUSION： Hepatic arterial chemoembolization in hepatocellular carcinoma patients after surgery is feasible and can improve the survival rate and reduce the relapse rate.