摘要
Notch信号通路是一条进化上高度保守的通路,广泛存在于各种生物细胞中,参与细胞增殖、分化等环节,精确介导细胞间信息交流.上皮-间充质现象(epithelium-mesenchymal transition,EMT)是细胞受到外界刺激而引起的应激反应,即上皮细胞在接受刺激后,激活一系列信号通路,最终向间充质细胞转化的过程.已有研究表明EMT是肝纤维化过程中的重要环节并受Notch信号通路调控,这说明Notch信号通路可以通过调控EMT介导肝纤维化的形成.本文就Notch信号通路在肝纤维化EMT环节中的具体作用机制作一综述.
Notch signaling is a conserved cellular interaction mechanism that widely exists in many kinds of cells. It can influence proliferation, differentiation and apoptotic cell fates, mediating interaction between cells. Epithelial-mesenchymal transition（EMT） is a process in which cells lose their epithelial phenotype and acquire mesenchymal cellular characteristics that enhance migration and invasion. This process is mediated by several cell signaling pathways. It has been proved that Notch signaling regulates EMT in hepatic fibrosis. This article will discuss how Notch signaling regulates EMT in hepatic fibrosis.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第30期4588-4592,共5页
World Chinese Journal of Digestology
基金
国家级大学生创新创业训练计划基金资助项目
No.201212121053
高等学校博士学科点专项科研基金资助项目
No.20134433120009~~
