Tregs在幽门螺杆菌感染中的作用

Role of Tregs in Helicobacter pylori infection

目的:探讨Tregs在人幽门螺杆菌(Helicobacter pylori,H.pylori)感染中的作用.方法:168例胃窦黏膜标本中H.pylori阳性89例,H.pylori阴性79例;60例H.pylori根除治疗前后患者的胃窦黏膜标本,均采用免疫组织化学的方法检测病理标本中Foxp3阳性细胞浸润情况.结果:H.pylori阳性组胃窦黏膜标本中Tregs浸润程度显著高于H.pylori阴性组(8.9%vs2.4%,P<0.01);H.pylori根除治疗前胃窦黏膜标本中Tregs浸润程度显著高于根除治疗后(9.1%vs 3.0%,P<0.01).结论:Tregs参与了H.pylori感染的免疫应答,H.pylori感染致胃黏膜Tregs浸润数量显著增加,抑制黏膜局部免疫反应,减轻免疫损伤的同时导致H.pylori逃逸机体的免疫清除,造成H.pylori持续慢性感染及黏膜慢性炎症;根除H.pylori后,胃黏膜Tregs浸润数量显著减少,黏膜可重新恢复免疫平衡状态.

AIM： To investigate the role of Foxp3＋ regulatory T cells（Tregs） in Helicobacter pylori（H. pylori） infection.METHODS： By using biopsies from 89 H. pyloripositive patients, 60 of whom underwent treatment for eradication of H. pylori, and 79 H. pylori-negative adults, immunohistochemistry was performed to semi-quantify the number of Tregs in the gastric mucosa.RESULTS： The proportion of Tregs was 2.4% in H. pylori-negative individuals, and 8.9% in H. pylori-positive patients（P〈0.01）. After eradication of H. pylori, the proportion of Tregs signifi-cantly declined（3.0%, P 〈0.01）.CONCLUSION： Tregs actively participate in the immune response to H. pylori infection. H. pylori chronically colonizes the stomach and increases the frequency of Tregs in the gastric mucosa, thereby suppressing the immune response and contributing to the persistence of H. pylori infection. Tregs decrease in the gastric mucosa after eradication of H. pylori, and mucosal immune balance is then restored.