台州市新报告HIV感染者中HBV合并感染研究

HBV Coinfection among Newly Diagnosed HIV-infected Adults in Taizhou of Zhejiang

目的 了解浙江省台州市2009-2012年新报告HIV感染者中合并感染乙型肝炎病毒（HBV）的情况,并探讨HIV/HBV合并感染者血浆HBV病毒载量水平.方法 采用横断面研究设计对2009-2012年台州市新报告的572例成年HIV感染者进行HBV表面抗原（HBsAg）检测,对HBsAg阳性标本进行HBV-DNA定量检测.结果 共有91例HIV感染者中HBsAg检测呈阳性,HBV合并感染率为15.9％.40 ～ 49岁年龄组感染者的HBV合并感染率显著高于50岁以上年龄组（OR=3.01,95％CI：1.24～7.29）;少数民族HIV感染者的HBV合并感染率显著高于汉族HIV感染者（OR=2.61,95％CI：1.04 ～ 6.52）;其他途径HIV感染者的HBV合并感染率,则低于经同性性接触感染者（OR=0.18,95％CI：0.04～0.90）.91例HIV/HBV合并感染者中仅26例（28.6％）血浆HBV病毒载量低于检测下限（5.0×102 IU/mL）,处于相对抑制状态.多因素Logistic回归分析未发现HIV/HBV合并感染者HBV相对抑制率与其社会人口学特征、HIV传播途径及CD4细胞计数等有显著关联.结论 台州市HIV感染者中存在一定比例的HBV合并感染者,其中仅少数患者HBV处于相对抑制状态.不同特征的HIV/HBV合并感染者中HBV-DNA相对抑制率未发现明显差异。

OBJECTIVE To determine the prevalence of hepatitis B virus（HBV） and correlates of Hepatitis B viremia levels among adults newly diagnosed with HIV in Taizhou of Zhejiang, China. METHODS Five hundred and seventy-two adults newly diagnosed with HIV in Taizhou were selected form 2009 to 2012. HBV infection was screened by HBsAg. HBV DNA was also detected and quantified if HBsAg was positive. RESULTS Overall, 91 participants were tested HBsAg positive and the prevalence of HBV co-in- fection was 15.9%. Participants between 40- 49 years old were shown to have higher HBV co-infection rate than those more than 50 （OR=3.01, 95%CI： 1.24-7.29）; people of minority had a higher HBV co-infection rate than Han（OR=2.61, 95%CI： 1.04- 6.52）; participants acquired HIV via other route of transmission had a lower HBV co-infection rate than those who infected HIV through homosexual（OR=0.18, 95%CI： 0.04 - 0.90）. 26 out of 91（28.6%） HIV/HBV co-infection participants had undetectable serum HBV-DNA loads（lowerthan the limit of detection 5.0-102 IU/mL）. It could detect no significant associations between HBV-DNA relative suppression rate and the demographics, HIV transmission route and CD4 T-cell counts according to multivariate logistic regression analyses. CONCLUSIONS The coinfection of HBV was prevalent among newly diagnosed HIV-infected adults in Taizhou of Zhejiang. Furthermoreonly a minority of them were in the HBV-DNA relative suppression state. It could not detect significant associations between HBV-DNA relative suppression rate and the characteristics of HIV patients.