胰腺癌转基因小鼠模型研究进展

Research Progress in Transgenic Mouse Models of Pancreatic Cancer

胰腺癌是人类恶性肿瘤中最为致命的一种,癌基因KRAS的突变,抑癌基因(如CDKN2A、SMAD4)的失活或缺失以及大量信号途径的变化是胰腺癌的重要特征。因此,为弄清胰腺癌的这些生物学行为以及制订合理的治疗方案,建立模拟胰腺癌发生、发展过程的实验动物模型显得尤为重要。目前,基于KRAS突变的转基因小鼠模型较好地模拟了胰腺癌的癌前病变过程,结合其他抑癌基因的缺失或突变,进一步展示了胰腺癌的进展过程,如侵袭和转移等。该文就胰腺癌转基因小鼠模型予以综述。

Pancreatic cancer is one of the most lethal human malignancies. The inactivation or deletions of oncogene KRAS mutations,tumor suppressor genes such as CDKN2 A,SMAD4 and changes in a large number of signaling pathways are important features of pancreatic cancer. Therefore,it is of great importance to establish suitable animal model to simulate the occurrence and development process of pancreatic cancer in order to understand the biological behavior of pancreatic cancer and design rational treatment programs.Currently,transgenic mouse models based on KRAS mutations can best simulate preneoplastic lesions of pancreatic cancer,which in combination with other tumor suppressor gene deletions or mutations,can further demonstrate the process of the progression of pancreatic cancer,such as invasion and metastasis. Here is to make a review of the research on transgenic mouse models of pancreatic cancer.