神经节苷脂治疗急性脑卒中患者的疗效及对血清中TNF-α和IL-6水平的影响

The Effect of Ganglioside Treatment of Patients with Acute Stroke and the Influence on Serum TNF-α and IL-6 Level

目的探讨神经节苷脂治疗急性脑卒中患者的效果及对血清中肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平的影响。方法选择2011年1月至2013年6月昆山市第一人民医院收治的急性脑卒中患者198例,依据治疗方法不同分为两组:对照组90例采用常规疗法治疗,观察组108例在对照组基础上应用神经节苷脂治疗。评价并比较两组患者的治疗效果、采用巴氏指数(BI)、肢体运动功能(FM)评分、神经功能缺损(NIHSS)评分,并测量治疗前后的血清TNF-α和IL-6水平。结果观察组总有效率为73.15%(79/108),高于对照组的62.23%(56/90),差异有统计学意义(P<0.05)。观察组BI和FM评分高于对照组[(59.74±0.59)分vs(56.10±0.62)分;(77.83±1.14)分vs(72.25±1.08)分],NIHSS评分低于对照组[(16.19±0.22)分vs(19.66±0.38)分],差异均有统计学意义(P<0.01)。两组患者治疗后血清TNF-α和IL-6水平均低于治疗前(P<0.01),且观察组均低于对照组,差异有统计学意义(P<0.01)。结论神经节苷脂治疗急性脑梗死效果显著,可降低TNF-α和IL-6水平,能够促进患者功能恢复。

Objective To explore the effect of ganglioside treatment of patients with acute stroke,and study the influence on tumor necrosis factor-α（ TNF-α） and interleukin-6（ IL-6） level. Methods A total of198 patients with acute cerebral stroke admitted to Kunshan First People＇ s Hospital from Jan. 2011 to Jun.2013 were divided into two groups according to random-number table method,90 cases with conventional treatment were in the control group,108 cases of the observation group treated with ganglioside based on the control group. Evaluation indexes were treatment effect,the Barthel index（ BI）,movement function（ FM）score,limb function defect degree of the neurological deficits（ NIHSS） score,and serum TNF-α and IL-6levels before and after treatment. Results The total effective rate of the observation group was 73. 15%（ 79 /108）,higher than that of the control group 62. 23%（ 56 /90）（ P〈0. 05）. BI and FM scores of the observation group were（ 59. 74 ± 0. 59） and（ 77. 83 ± 1. 14）,control group were（ 56. 10 ± 0. 62） and（ 72. 25 ±1. 08）; NIHSS of the observation group was（ 16. 19 ± 0. 22）,lower than that of the control group（ 19. 66 ±0. 38）（ P〈0. 01）. TNF-α and IL-6 concentrations of the two groups after treatment were lower than those before therapy（ P〈0. 01）; TNF-α and IL-6 concentrations of the observation group after treatment were lower than the control group,the difference was statistically significant（ P〈0. 01）. Conclusion Ganglioside treatment for the acute cerebral infarction has significant effect,which can reduce the concentration of TNF-αand IL-6 and promote the function recovery of the patients.