蜂毒蜜点涂佐治小儿急性细菌性扁桃体炎的疗效与安全性

The efficacy and safety of the adjuvant Treatment of the children with acute bacterial tonsillitis by pointing the Honey Bee Venom

目的:评价蜂毒蜜点涂佐治小儿急性细菌性扁桃体炎的临床疗效与安全性。方法:将符合本方案入选条件的患儿125例,随机分成治疗组和对照组,其中治疗组为64例,对照组为61例。治疗组在口服头孢克洛颗粒的基础上,用蜂毒蜜1ml点涂咽部两侧与双侧扁桃体,每天2次,疗程5d;对照组仅口服头孢克洛颗粒,不用蜂毒蜜点涂,疗程相同。结果:治疗组48小时退热率为73.4%,总有效率为100%,不良反应率为3.1%。对照组48小时退热率为55.7%,总有效率为90.2%,不良反应率为1.6%。经统计学处理:两组临床疗效有显著性差异(P<0.05);两组不良反应发生率比较,差异无统计学意义(χ2=1.77,P>0.05)。结论:蜂毒蜜点涂佐治小儿急性细菌性扁桃体炎安全、有效,易于被患儿接受。

Objective：To assess the efficacy and safety of the adjuvant treatment of the children with acute bacterial tonsillitis by pointing the honey bee Venom. Methods：To divide 125 patients into two groups randomly-the treatment group （sixty four） and the control group （sixty one）. On the basis of oral cefaclor granules,the treatment group were pointed on the pharynx and bilateral amygdala with the one milliliter of the honey bee venom, twice a day for five days, and control group only with oral cefaclor particles for five days. Results： The treatment group showed antipyretic rate of 73.4% within 48 hours and the total effective rate was 100% with the rate of adverse events of 3.1%. The control group showed antipyretic rate of 55.7% within 48 hours, the total effective rate was 90.2%, the incidence rate of adverse events of 1.6%; After the statistics treatment, the significant difference was seen between the two groups in the antipyretic rate within 48 hours and clinical curative effect （P〈0.05）. No statistical significant difference was seen between two groups in the incidence of adverse events（χ^2=.77,P〉0.05）.Conclusion： The adjuvant treatment with pointing honey bee venom was safe, effective, and easily acceptant in the children with acute bacterial tonsillitis.