342株肠球菌的临床分类及耐药性分析

The Clinical Distribution and Analysis of Drug Resistance of 324 Strains of Enterococcus

目的:了解肠球菌的临床分离率及其对常用抗生素的耐药性,指导临床合理使用抗生素。方法:用Vitek 2 Compact法进行细菌鉴定及常规药敏试验。结果:临床分离到的342株肠球菌中,粪肠球菌有140例,阳性率40.9%,屎肠球菌有186例,阳性率54.4%,其它肠球菌有16例,阳性率4.7%。342株肠球菌主要分离自尿液254例,阳性率74.3%;血液28例,阳性率8.2%;脑脊液21例,阳性率6.1%;胆汁15例,阳性率5.3%。屎肠球菌对青霉素、氨苄西林、环丙沙星、左氧氟沙星、红霉素和四环素的耐药率已接近或达到90%,而粪肠球菌对青霉素和氨苄西林仍保持100%敏感性。未发现肠球菌对万古霉素、利奈唑胺和替加环素耐药。结论:革兰阳性球菌中肠球菌是引起医院感染的重要病原菌之一,肠球菌引起的感染性疾病的治疗一定要以药敏结果为指导合理选用抗生素。

Objective：To understand the distribution and drug resistance of commonly used antibiotics of enterococcus, in order to provide the basis for clinical rational drug use. Methods：Vitek 2 Compact method was used for routine bacteria identification and drug susceptibility test. Results： Among clinical isolated 342 strains of enterococcus, 140 cases were 40.9% in enterococcus, excrement enterococcus 186 rate of 54.4%;other enterococcus 16 cases were 4.7%. 342 strains of enterococcus were mainly isolated from urine of 254 cases （74.3%）, 28 cases （8.2%） and blood cerebrospinal fluid 21 cases （6.1%）, 15 cases （5.3%） of bile. Excrement enterococcus to penicillin, ampicillin, ciprofloxacin, levofloxacin, erythromycin and tetracycline resistance was close to or reached 90%, and dung bowel aureus to penicillin and ampicillin remained 100%sensitivity. There were no resistance to enterococcus among vancomycin, rina thiazole amine and Tigecycline. Conclusion： Enterococcus was one of the important pathogenic bacteria in hospital infection. According to the results of drug susceptibility, clinical treatment of enterococcus infection should choose reasonable antibiotics.