吲哚菁绿排泄试验与肝脏储备功能的相关性评价

The relevance evaluation of indocyanine green excretion test in the hepatic functional reserve

目的探讨吲哚菁绿(ICG)排泄试验在肝脏储备功能评估中的临床价值。方法选取2012年1月至2014年5月吉林大学中日联谊医院接受吲哚菁绿排泄试验的肝脏疾病患者119例,分别测定ICG 15分钟滞留率(R15)、血浆清除率(K)、有效肝血流量(EHBF),并采用Child-Pugh分级、MELD评分及t检验、线性回归分析,比较R15、K值与Child-Pugh分级、MELD评分的关系。结果随着Child-Pugh分级的递增,K值和EHBF下降,而R15升高。Child-Pugh A组R15(12.289±12.754)%,K值(0.172±0.069)/min;Child-Pugh B组R15(41.818±17.202)%,K值(0.063±0.026)/min;两组R15、K值比较存在统计学差异(P<0.05)。将R15、K值与Child-Pugh分级、MELD评分进行相关性分析,均存在良好相关性,R15为正相关,K值为负相关。结论 R15、K值与Child-Pugh分级关系密切,R15相关性更加显著,提示R15是评估肝脏储备功能的准确、灵敏指标。

Objective To assess the clinical value of indocyanine green excretion test in the evaluation of hepatic functional reserve.Methods Collect 119 patients with liver disease accepting the examination of indocyanine green excretion test who were from hospitalized in the China-Japan Union Hospital of Jilin University from January,2012 to May,2014.The ICG excretion test（R15,K value and EHBF）was performed,which used Child-Pugh grade,MELD scores and t test,linear regression analysis,comparing relationship between R15,K value and Child-Pugh grade,MELD scores.Results Along with the Child-Pugh grade increase,K value and EHBF declined,while R15 increased.In ChildPugh A group,R15was（12.289±12.754）%,K value was（0.172±0.069）/min;in Child-Pugh B group,R15was（41.818±17.202）%,K value was（0.063±0.026）/min;there were significant difference in R15 and K value between both groups.Correlation analysis between R15,K value and Child-Pugh grade,MELD scores,there were good correlation,R15 was positive correlation,K value was negative correlation.Conclusion There were close relations between R15,K value and Child-Pugh grade.R15 showed more significant correlation which was to evaluate the accuracy andsensitivity index of hepatic functional reserve.