贝尔麻痹影响大脑默认模式网络的功能连接(英文)

Facial Bell's palsy affects default mode network connectivity

目的贝尔麻痹是一种常见的特发性面神经病变,导致病变侧的面部肌肉运动功能丧失。作者探讨了贝尔麻痹对大脑默认模式网络(DMN)功能连接的影响。材料与方法使用1.5 T MR成像仪获取静息态f MRI数据,包括健康志愿者35名及不同病理状态下的面瘫患者52例次。使用双重回归独立成分分析方法处理数据。结果发现面瘫不同病理状态下DMN的功能连接发生了不同的变化。在面瘫疾病早期,DMN功能连接在右侧初级感觉皮层、初级运动皮层、背外侧前额叶显著增强;在面瘫后期,DMN功能连接在双侧中扣带回、楔前叶、右侧富内侧前额叶、后扣带回显著增强;在面瘫康复后,DMN功能连接在左侧舌回、小脑显著增强。结论在面瘫不同病理阶段,DMN的功能连接存在着明显的不同,涉及到感觉运动,运动映射,情感以及认知等不同功能脑区。

Objective： Bell＇s palsy（BP） is common peripheral idiopathic disease affecting the facial nerve（CN VII） causing loss of control facial muscles on the affected side. We investigated BP＇s effects on the resting state default mode network（DMN） connectivity due to neuroplasticity in brain. Materials and Methods： 1.5 T- MRI scanner was used to aquire fMRI data over 35 healthy volunteers and 52 BP patients（Some of patients participated more than once） at different pathological stages（based on disease duration and House-Brackmann Score） in resting state. Dual regression independent component analysis（ICA） approach was used for functional connectivity analysis. Results： DMN connectivity had varied changes for different stages of BP. In early group, DMN connectivity was increased with right（r.） SI, r. MI, and r. DLPFC; while for late group it was increased with bilateral MCC, r. VMPFC, r. PCC, bilateral precuneus. For recovered group, DMN connectivity was increased with left（l.） lingual gyrus and l. cerebellum. Conclusions： BP induced different DMN brain connectivity changes with different brain regions such as sensorimotor, motor mapping, emotional regions and cognitive regions and this connectivity changes are varied between different pathological stages.