酪酸梭菌二联活菌散联合消旋卡多曲治疗婴幼儿病毒性腹泻的疗效

Combined Clostrdium Butyricum and Bifidobacterium Powders,live Combined with Racecadotril for Infantile Viral Diarrhea

目的探讨酪酸梭菌二联活菌散联合消旋卡多曲在婴幼儿腹泻中的治疗效果。方法将120例腹泻的婴幼儿按随机数字表法分为观察组和对照组,每组60例。对照组给予酪酸梭菌二联活菌散治疗,观察组在对照组治疗的基础上加用消旋卡多曲治疗。对2组患儿疗效、临床症状缓解(大便好转、退热、止泻)时间及治疗前、治疗72 h后症状积分(腹泻、腹痛、腹胀、大便异常)进行比较。结果观察组总有效率为90.0%,对照组总有效率为75.0%,2组比较差异有统计学意义(P<0.05)。观察组大便好转、退热及止泻时间均短于对照组(均P<0.05)。2组患儿治疗前症状积分比较差异无统计学意义(P>0.05);治疗72 h后2组症状积分均明显低于治疗前、观察组的各项症状积分均明显低于对照组(均P<0.05)。2组均未见明显的不良反应。结论酪酸梭菌二联活菌散联合消旋卡多曲能提高婴幼儿腹泻的治疗效果,且起效迅速,不良反应少,服用安全。

Objective To investigate the efficacy of Changlekang （combined clostridium butyricum and bifidobacterium powders, live） and racecadotril in the treatment of infantile diarrhea. Methods A total of 120 infants with diarrhea were randomly treated with Combined clostrdium butyricum and bifidobacterium powders,live （control group, n=60） or in combination with racecadotril （observation group, n=60）. The efficacy and time to symptom remission （improvement defecation, abatement of fever and cessation of diarrhea） were compared between the two groups. In addition, the symptom scores （diarrhea, abdominal pain, abdominal distension and abnormal defecation） were measured before and after treatment for 72 hours. Results The total effective rate in observation group was significantly higher than that in control group（90.0%vs 75.0%,P〈0.05）.The time to symptom remission in observation group was significantly shorter than that in control group （P〈0.05）. There were no obvious differences in symptom scores between the two groups before treatment（P〉0.05）.After treatment for 72 hours, symptom scores markedly decreased in both groups, and observation group had a significantly lower symptom scores than control group （P〈0.05）. No obvious adverse reactions were found in both groups. Conclusion Changlekang combined with racecadotril is an effective, fast and safe treatment and leads to fewer adverse effects on infantile diarrhea.