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卒中后抑郁神经生物学发病机制研究进展 被引量:5

Research progress on post-stroke depression neurobiological mechanisms
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摘要 卒中后抑郁发病机制复杂,涉及生物学、心理学及社会学等多个方面,具有发病率、漏诊率高,治愈率低等特点.由脑卒中引起的神经内分泌功能紊乱,重要脑区功能缺失及神经递质缺乏均可引发抑郁情绪,而卒中后炎症反应导致的脑损害亦可加重病情,导致卒中后抑郁的产生.近年来,科学提供的便利使卒中后抑郁的遗传易感性得到深入研究,敏感基因的发现为卒中后抑郁预测提供了可能性,成为目前研究热点.本文对其神经递质、神经内分泌、神经解剖等神经生物学方面发病机制的相关研究进行了回顾,旨在为提高对卒中后抑郁的认识、诊断及治疗提供帮助. The pathogenesis of poststroke depression is complex, is involved multiple aspects such as biology, psychology, sociology and so on, and is characterized by high disease incidence and rate of missed diagnosis and low cure rate. Neuroendocrine dysfunction due to stroke, afunction of important encephalic region and neurotransmitters' deficiency all can cause depressive emotion, brain damage caused by poststroke inflammatory reaction can aggratate patient's condition and lead to the generation of poststroke depression. In recent years the genetic susceptibility to poststroke depression has been deeply studied on the basis of the convenience provided by science, the discovery of sensitive gene provide the possibility for poststroke depression prediction and become research hotspot. In this paper pathogeneses involving neurobiological aspects such as neurotransmitter, neuroendocrine and neuroanatomy were reviewed in order to improve the understanding of poststroke depression and provide help for diagnosis and treatment.
出处 《临床心身疾病杂志》 CAS 2014年第6期76-79,共4页 Journal of Clinical Psychosomatic Diseases
基金 新乡市科技创新平台建设项目(编号CP1305)
关键词 卒中后抑郁 神经生物学 发病机制 神经递质学说 神经内分泌学说 神经解剖学说 炎性细胞因子学说 脑源性神经营养因子学说 PSD neurobiology pathogenesis neurotransmitter theory neuroendocrinology theory neuroanatomy theory inflammatory cytokines theory brain-derived neurotrophic factor theory
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  • 1Feigin VL,Forouzanfar MH,Krishnamurthi R,et al.Global and regional burden of stroke during 1990-2010:findings from the Global Burden of Disease Study 2010[J].Lancet,2014,383(9913):245.
  • 2胡华廷,高金香,吕应春,宋景贵.心理干预对脑卒中后抑郁患者临床疗效的影响[J].临床心身疾病杂志,2011,17(6):557-558. 被引量:3
  • 3Ayerbe L,Ayis S,Wolfe CD,et al.Natural history,predictors and outcomes of depression after stroke:systematic review and meta-analysis[J].Br J Psychiatry,2013,202(1):14.
  • 4龙金亮,朱玉星,孙群星,杨建章.舍曲林联合认知疗法治疗脑卒中后抑郁疗效评价[J].临床心身疾病杂志,2011,17(3):263-264. 被引量:6
  • 5宋丽,余学,曹一,赵燕华.氟西汀联合喹硫平治疗脑卒中后抑郁症对照研究[J].临床心身疾病杂志,2011,17(5):398-399. 被引量:17
  • 6曹金霞,耿德勤,姜建东,刘莉,姜玉龙,孙德锦.5-羟色胺转运体基因多态性与脑卒中后抑郁的关系[J].中国实用神经疾病杂志,2011,14(24):17-19. 被引量:10
  • 7Mak KK,Kong WY,Mak A,et al.Polymorphisms of the serotonin transporter gene and post-stroke depression:a meta-analysis[J].J Neurol Neurosurg Psychiatry,2013,84(3):322.
  • 8Kim JM,Stewart R,Kang HJ,et al.A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression[J].J Psychiatr Res,2013,47(9):1222.
  • 9Kronenberg G,Balkaya M,Prinz V,et al.Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression[J].Biol Psychiatry,2012,72(4):273.
  • 10Fehen A,Montag C,Markett S,et al.Genetically determined dopamine availability[J].Brain Behav,2011,1 (2):109.

二级参考文献122

共引文献61

同被引文献83

  • 1乔明琦,王文燕,张惠云,徐旭杰,韩秀琴,慈玉珍,叶青.肝气逆肝气郁两证病因流行病学调查及情志致病方式研究[J].中国中西医结合杂志,2007,27(2):117-119. 被引量:38
  • 2高向丽,过伟峰.中风后抑郁症病机特点探析[J].辽宁中医药大学学报,2007,9(2):41-42. 被引量:25
  • 3Kelly PJ, Morrow JD, Ning M, et al. Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study [J]. Stroke, 2008, 39(1), 100-104.
  • 4Tsakanova GV, Ayvazyan VA, Boyajyan AS, et al. A comparative study of antioxidant system and intensity of lipid peroxidation in type 2 diabetes mellitus and ischemic stroke aggravated and not aggravated by type 2 diabetes mellitus [J]. BullExp Biol Med, 2011, 151(5): 564-566.
  • 5Vassalle C, Botto N, Andreassi MG, et al. Evidence for enhanced 8-isoprostane plasma levels, as index of oxida tive stress in vivo, in patients with coronary artery disease [J]. Coronary Artery Dis, 2003, 14(3) : 213-218.
  • 6Nemzer BV, Rodriguez LC, Hammond L, et al. Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage a pi- lot clinical study with phytochemical and in vitro antioxidant characterization [J]. Nutrition Journal, 2011, 10(6) : 67.
  • 7Yu W, Ying H, Tong F, et al. Protective effect of the silkworm protein 30Kc6 on human vascular endothelial cells damaged by oxidized low density lipoprotein (Ox-LDL) [J]. PLoS One, 2013, 8(6): e68746.
  • 8齐英斌,白春艳,周艳,刘敏,马爽,孙宏侠,江新梅.超敏C反应蛋白变化与缺血性脑卒中的研究[J].中国实验诊断学,2009,13(9):1188-1189. 被引量:9
  • 9郑绍勇,梅晓云.七情疾病的气机理论[J].光明中医,2009,24(11):2088-2089. 被引量:2
  • 10刘书考,严灿,吴丽丽,潘毅.“肾藏志应恐”有关神经生物学机制的研究思路[J].中西医结合学报,2010,8(2):106-110. 被引量:9

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