期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肾母细胞瘤基因表达及治疗的研究进展 被引量：1

Research progress on gene expression and treatment of wilms＇ tumor
原文传递
导出
摘要 肾母细胞瘤是儿童中最常见的实体瘤之一,其基因表达与肿瘤的发生、发展及预后密切相关,目前治疗方案不断改进,包括术前化疗、保留肾单位手术及肿瘤干细胞的靶向治疗,旨在维持较高生存率的同时减少治疗相关毒性.该文就肾母细胞瘤基因表达和治疗措施作一综述. Nephroblastoma is one of the most common solid tumours in children,and the gene expression is closely related to the tumorigenesis,development and prognosis.The treatment regimens have been constantly updated,which includes the preoperative chemotherapy,nephron-sparing surgery and targeted therapy of cancer stem cells,aiming to maintain the excellent survival for children being treated for Wilms tumor,while minimizing therapy-related toxicity.This paper reviews the gene expression and treatment on wilms＇ tumor.
作者 李赟颉 殷丽萍 陆超
机构地区 南京医科大学第一附属医院儿科
出处 《国际儿科学杂志》 2014年第6期573-576,共4页 International Journal of Pediatrics
关键词 肾母细胞瘤 基因表达 治疗 Nephroblastoma Gene expression Therapy
分类号 R737.11 [医药卫生—肿瘤]
  • 相关文献

参考文献33

  • 1夏洵,鹿玲.足细胞转录因子和肾脏疾病研究进展[J].国际儿科学杂志,2006,33(6):385-387. 被引量：3
  • 2Hamilton TE,Shamberger RC.Wilms tumor:recent advances in clinical care and biology[J].Semin Pediatr Surg,2012,21 (1):15-20.
  • 3Li CM,Guo M,Borczuk A,et al.Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition[J].Am J Pathol,2002,160 (6):2181-90.
  • 4Brockmann A,Amore G,Casares F,et al.Regulation of ocellar specification and size by twin of eyeless and homothorax[J].Dev Dyn,2011,240(1):75-85.
  • 5Fukuzawa R,Breslow NE,Morison IM,et al.Epigenetic differences between Wilms' tumours in white and east-Asian children[J].Lancet,2004,363 (9407):446-451.
  • 6Singh P,Lee DH,Szabo PE.More than insulator:multiple roles of CTCF at the H19-IGF-2 imprinted domain[J].Front Genet,2012,3 (1):214-223.
  • 7Hubertus J,Lacher M,Rottenkolber M,et al.Altered expression of imprinted genes in Wilms tumors[J].Oncol Rep,2011,25 (3):817-823.
  • 8Schulz R,McCole RB,Woodfine K,et al.Transcript-and tissue-specific imprinting of a tumour suppressor gene[J].Hum Mol Genet,2009,18(1):118-127.
  • 9Evans HK,Wylie AA,Murphy SK,et al.The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2[J].Genomics,2001,77 (1-2):99-104.
  • 10Hubertus J,Zitzmann F,Trippel F,et al.Selective methylation of CpGs at regulatory binding sites controls NNAT expression in Wilms tumors[J].PloS one,2013,8 (6):e67605.

二级参考文献60

  • 1张慧琼,易著文,何小解,党西强,何庆南,莫双红.Pax2在肾病综合征糖皮质激素耐药中的作用[J].中南大学学报（医学版）,2005,30(5):597-600. 被引量：3
  • 2Dammann R, Yang G, Pfeifer GP, Hypermethylation of the CpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers[J]. Cancer Res, 2001,61(7):3105-3109.
  • 3Yoon JH, Dammann R, Pfeifer GP. Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas[J]. Int J Cancer, 2001, 94(2) :212-217.
  • 4Lo KW, Kwong J, Hui AB, et al. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma [J].Cancer Res, 2001, 61:3877-3881.
  • 5Astuti D, Agathanggelou A, Honorio S, et al. RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma turnouts [ J ]. Oncogene, 2001, 20 ( 51 ) : 7573-7577.
  • 6Maruyama R, Toyooka S, Toyooka KO, et al. Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features [ J ]. Clin Cancer Res, 2002, 8 ( 2 ) : 514-519.
  • 7Kang GH, Lee S, Kim WH, et al. Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotypepositive gastric carcinoma [ J ]. Am J Pathol, 2002, 160 ( 3 ):787-794.
  • 8Nakagawa H,Chadwick RB, Peltomaki P, et al. Loss of imprinting of the insulin-like growth factor Ⅱ gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer[J].Proc Natl Acad Sci USA, 2001, 98(2):591-596.
  • 9Michael I, Lerman, John D. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3 : identification and evaluation of the resident candidate tumor suppressor genes [ J ].Cancer Res, 2000, 60:6116-6133.
  • 10Dammann R, Li C, Yoon JH, et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3[J]. Nature genetics, 2000,25:315-319.

共引文献17

同被引文献28

  • 1ParodiS, MerloDF, RanucciA, et al.Risk of neuroblastoma, maternal characteristics and perinatal exposures:the SETIL study[J].Cancer Epidemiol, 2014, 38(6):686-694.
  • 2OrbachD, SarnackiS, BrisseHJ, et al.Neonatal cancer[J].Lancet Oncol, 2013, 14(13):e609-620.
  • 3ChuA, HeckJE, RibeiroKB, et al.Wilms' tumour:a systematic review of risk factors and meta-analysis[J].Paediatr Perinat Epidemiol, 2010, 24(5):449-469.
  • 4GhoshJK, HeckJE, CockburnM, et al.Prenatal exposure to traffic-related air pollution and risk of early children cancers[J].Am J Epidemiol, 2013, 178(8):1233-1239.
  • 5FairlieI.A hypothesis to explain childhood cancers near nuclear power plants[J].J Environ Radioact, 2014, 133:10-17.
  • 6CarpenterDO, Bushkin-BedientS.Exposure to chemicals and radiation during childhood and risk for cancer later in Life[J].J Adolesc Health, 2013, 52(5Suppl):S21-29.
  • 7Leith SlyJ, CarpenterDO.Special vulnerability of children to environmental exposures[J].Rev Environ Health, 2012, 27(4):151-157.
  • 8VizcainoE, GrimaltJO, Fernández-SomoanoA, et al.Transport of persistent organic pollutants across the human placenta[J].Environ Int, 2014, 65:107-115.
  • 9HerbstAL, UlfelderH, PoskanzerDC.Adenocarcinoma of the vagina.Association of maternal stilbestrol therapy with tumor appearance in young women[J].N Engl J Med, 1971, 284(15):878-881.
  • 10CooneyMA, DanielsJL, RossJA, et al.Household pesticides and the risk of Wilms tumor[J].Environ Health Perspect, 2007, 115(1):134-137.

引证文献1

二级引证文献7

国际儿科学杂志
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部