血管内皮生长因子及胰岛素样生长因子-1在早产儿视网膜病变中的作用

Roles of vascular endothelial growth factor and insulin-like growth factor-1 in retinopathy of prematurity

早产儿视网膜病变（retinopathy of prematurity,ROP）多发生于早产儿尤其是极低出生体重儿,是导致儿童视力下降甚至失明的重要原因.视网膜新生血管形成是其主要的病理特点,血管内皮生长因子（vascular endothelial growth factor,VEGF）及胰岛素样生长因子-1（insulin like growth factor-1,IGF-1）通过控制血管内皮细胞增殖,在新生血管形成中起到了关键作用.近年来临床研究表明,玻璃体内注射VEGF抑制剂及生后早期提高早产儿血清IGF-1水平是防治ROP的有效方法.该文以国内外相关研究为背景,综述VEGF及IGF-1在早产儿视网膜病变发病过程中的作用,以及针对其作用机制而采取的防治方法.

Retinopathy of prematurity （ROP）occurs in the premature infant especially very low birth weight infants.It is an important reason which cause vision loss in children.The main pathological feature of ROP is retinal neovascularization.Vascular endothelial growth factor （VEGF） and insulin-like growth factor-1 （IGF-1） play a vital role in neovascularization by controlling the proliferation of vascular endothelial cells.In recent years many clinical studies have shown that intravitreal injection of anti-VEGF and increasing serum IGF-1 level of premature infants in early time is an effective method to prevent ROP.This article,according to the background of domestic and foreign relevant researches,reviews roles of VEGF and IGF-1 in ROP.