线粒体通道转换孔与新生儿缺血缺氧性脑损伤的研究进展

Mitochondrial permeability transition pore and hypoxic-ischemia brain damage in neonates

线粒体通道转换孔（mitochondrial permeability transition pore,mPTP）是一种横跨于线粒体内外膜之间,由多种特殊蛋白构成的非特异性、电压依赖性的蛋白复合物通道.缺血缺氧时,线粒体的膜通透性改变,影响线粒体的功能,最终导致细胞死亡.围生期窒息导致的缺血缺氧性脑损伤（hypoxic-ischemia brain injury,HIBI）是威胁新生儿生命及导致神经后遗症的严重疾病,而线粒体功能障碍在HIBI发生过程中起重要作用.该文主要阐述mPTP与HIBI之间的关系.

Mitochondrial permeability transition pore plays a central role in alterations of mitochondrial structure and function,leading to neuronal injury,which is a nonspecific,voltage dependence of complex channel.Hypoxia-ischemia can affect the function of mitochondria,causing mPTP permeability change and leading to cell death.Hypoxia-ischemia brain injury（HIBI） which is caused by perinatal asphyxia threatens neonatal life and leads to neurological sequelae of severe diseases.And mitochondrial dysfunction plays an important role in HIBI.This paper mainly elaborates the relationship between the mPTP and HIBI.