养心安神汤治疗冠心病合并抑郁症的疗效观察

Clinical observation of nourishing heart and tranquilization decoction in treating stable coronary disease associated with depression

[目的]观察养心安神汤治疗冠心病合并抑郁症的临床疗效。[方法]将80例冠心病合并抑郁症患者随机分为对照组(常规扩冠治疗+喜普妙)和治疗组(常规扩冠治疗+养心安神汤),每组40例,在治疗前、治疗2周、4周、8周后进行汉密尔顿抑郁量表(HAMD)测评。对照组和治疗组均在治疗前后进行西雅图心绞痛量表(SAQ)的测评。[结果]治疗组完成35例,脱落5例,对照组完成37例,脱落3例。对照组治疗8周后HAMD量表得分(8.80±2.77)分,与治疗组(9.03±2.99)分比较差异无统计学意义(P>0.05),而在SAQ方面,治疗组在心绞痛稳定程度(AS)、心绞痛发作情况(AF)、治疗满意程度(TS)3个方面较对照组改善更明显(P<0.05)。[结论]养心安神汤治疗冠心病合并抑郁症疗效优于单纯扩冠药合并抗抑郁药的治疗效果。

[Objective] To observe the clinical curative effect of nourishing heart and tranquilization decoction in treating coronary heart disease associated with depression. [Methods] The 80 patients with coronary heart disease with depression were randomly divided into control group（Western medicine for expanding coronary vessels and Citalopram） and treatment group（routine Western medicine for expanding coronary vessels added with nourishing heart and tranquilization decoction）. In these two groups HAMD scale assessment was performed before treatment, 2 weeks, 4 weeks, 8 weeks after treatment. The treatment group and control group were also received Seattle Angina Questionnaire（SAQ） measurement before and after treatment. [Results] In the treatment group,35 patients completed the trial and 5 patients dropped out. In the control group,37 patients completed the trial and 3 patients dropped out. There was no statistical difference（P〉0.05） of HAMD scale score between the control group（8.80 ±2.77） and the treatment group（9.03 ±2.99）, while in terms of SAQ, the treatment group was improved more significantly（P〈0.05） in three aspects of AS, AF and TS. [Conclusion] Effect of nourishing heart and tranquilization decoction on coronary heart disease with depression is better than the simple expanding coronary medicine combined with antidepressants.