泼尼松联合来氟米特治疗老年类风湿关节炎的疗效及安全性

Effect and safety of prednisone combined with leflunomide treatment for elderly patients with rheumatoid arthritis

目的评价泼尼松联合来氟米特(LEF)治疗老年类风湿关节炎的有效性和安全性。方法回顾性分析我院2012年1-9月收治的50例类风湿关节炎患者应用小剂量泼尼松联合LEF治疗的临床资料。结果50例患者中显效33例,有效13例,总有效率为92%。不良反应为胃肠道反应、口腔溃疡、白细胞减少、肝损害和血糖升高。结论泼尼松联合来氟米特辅以有效的处理措施治疗老年类风湿关节炎安全有效,不良反应小。

Objective To evaluate the efficacy and safety of prednisone combined with leflunomide（ LEF） on elderly patients with rheumatoid arthritis. Methods The records of 50 cases of elder patients with rheumatoid arthritis treated with prednisone and LEF were retrospectively reviewed. Results Out of 50 cases,33 cases were remarkable ef-fective,13 cases were effective,the total effective rate was 92. 0%. The adverse reactions included gastrointestinal reac-tions,oral ulcers,leucopenia,liver damage and blood sugar increasing. Conclusion Prednisone combined with LEF plus appropriate management is effective and safe for the elderly patients with rheumatoid arthritis with less adverse reactions.