慢性非细菌性前列腺炎患者前列腺液中IL-6和IL-22水平的研究

Levels of IL-6 and IL-22 in expressed prostatic secretion of patients with chronic abacterial prostatitis

目的比较慢性非细菌性前列腺炎（CAP）患者与正常人前列腺液（EPS）中细胞因子IL-6和IL-22的水平。方法选择24例CAP患者为实验组和10例健康人为对照组,分别取两组受试者的EPS,采用ELISA法检测其IL-6和IL-22水平。结果实验组IL-6值11.65 pg/ml（4.42-17.78 pg/ml）,IL-22值（8.64±2.58）pg/ml;对照组IL-6值3.52 pg/ml（2.76-8.32 pg/ml）,IL-22值（9.31±2.26）pg/ml。实验组IL-6水平显著高于对照组（P〈0.01）,但两组之间的IL-22水平差异无统计学意义（P〉0.05）。结论 IL-6可能与CAP之间存在一定的关系,IL-6可能具有调节前列腺局部免疫反应的作用;而IL-22与CAP之间无明显联系,我们推测IL-22可能不参与前列腺的局部免疫反应。

Objective To compare the levels of IL-6 and IL-22 in expressed prostatic secretion（EPS） of between patients with chronic abacterial prostatitis（CAP） and healthy men. Methods Twenty-four patients with CAP were chosen as experimental group, and 10 healthy people were chosen as control group. The levels of IL-6and IL-22 in EPS were detected by ELISA. Results The levels of IL-6 and IL-22 of experimental group were11.65 pg/ml（4.42~17.78 pg/ml） and（8.64±2.58） pg/ml. The levels of IL-6 and IL-22 of control group were 3.52 pg/ml（2.76~8.32 pg/ml） and（9.31±2.26） pg/ml. Compared with the control group, the levels of IL-6 in experimental group was significantly higher（P〈0.01）, and the levels of IL-22 in experimental group showed no statistically significant difference（P〉0.05）. Conclusion There may be a certain relation between IL-6 and CAP. IL-6 may regulate local immune response of prostate. There is no obvious relation between IL-22 and CAP, which indicates that IL-22 may not participate in the local immune response of prostate.