罗哌卡因配伍小剂量氯胺酮自控硬膜外镇痛用于分娩镇痛的效果分析

The clinical effect of ropivacaine combined with low- dose ketamine controlled epidural analgesia in labor analgesia

目的探讨罗哌卡因配伍小剂量氯胺酮自控硬膜外镇痛用于分娩镇痛的临床效果。方法选择自愿接受分娩镇痛单胎初产妇130例,随机将其分为观察组与对照组,每组各65例。产程开始后,观察组注射罗哌卡因配伍小剂量氯胺酮,对照组仅注射罗哌卡因,观察两组产妇的镇痛效果、产程时间、缩宫素使用情况、分娩方式、产后2 h出血量以及新生儿情况等。结果给药后1 h、2 h两组产妇疼痛程度比较差异有统计学意义(P<0.05);两组在顺产率、器械助产率、剖宫产率和催产素使用率方面比较,差异均无统计学意义(P>0.05)。结论罗哌卡因配伍小剂量氯胺酮在自控硬膜外分娩镇痛中的应用是安全、有效的,可以减轻产妇的痛苦并且对母婴无不良反应,值得在临床上推广和应用。

Objective To investigate the clinical effect of ropivacaine combined with low- dose ketamine controlled epidural analgesia for labor analgesia. Methods 130 singletons primipara voluntarily adopted labor analgesia were randomly divided into observation group and control group with 65 cases in each group. Cases in observation group were given ropivacaine combined with low- dose ketamine,cases in control group were given ropivacaine. The analgesic effect,duration of labor,oxytocin usage,mode of delivery,postpartum 2h hemorrhage amount,and neonatal condition were observed. Results The difference of pain degree of puerpera 1h,2h after administration between two groups had statistical significance（ P〈0. 05）. The difference of vaginal delivery rate,instrumental delivery rate,caesarean section rate,oxytocin use rate between two groups had no statistical significance（ P〈0. 05）.Conclusion The ropivacaine combined with low- dose ketamine controlled epidural analgesia for labor analgesia is safe and effective which can alleviate the suffering of maternal without adverse reactions.