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原癌基因Bmi-1在肿瘤形成中的研究进展 被引量：2

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摘要 Bmi-1即B细胞特异的莫洛尼鼠白血病病毒插入位点-1基因（B-cell specific moloney murine leukemiavirus insertion site-1,Bmi-1）是一种癌基因,属于多梳基因家族（polycomb group genes Pc G）成员之一,是PRCI complex或E2F6 complex的组成成员,可调节同源盒（HOX）基因的转录[1]。
作者 唐晓琳 李瑶 杨永秀
机构地区 兰州大学第一临床医学院 甘肃省第三人民医院妇产科
出处 《中国临床研究》 CAS 2014年第11期1418-1420,1423,共4页 Chinese Journal of Clinical Research
关键词 原癌基因Bmi-1 多梳基因家族 细胞增殖 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献34

  • 1Arias AM. Epithelial mesenchymal interactions in cancer and devel- opment[J]. Cell,2001,105(4) :425 -431.
  • 2Haupt Y, Alexander WS, Barri G,et al. Novel zinc finger gene impli- cated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice[ J]. Cell, 1991,65 (5) :753 - 763.
  • 3Haga K, Ohno S, Yugawa T, et al. Efficient immortalization of primary human cells by pl61NK4a-specific short hairpin RNA or Bmi-1, com- bined with introduction of hTERT[ J ]. Cancer Sci,2007,98 (2) :147 - 154.
  • 4Tetrai P, Szepesi A, Matula Z, et al. Combined introduction of Bmi-1 and hTERT immortalizes human adipose tissue - derived stromal cells with low risk of transformation[ J]. Biocbem Biophys Res Commun, 2012,422( 1 ) :28 -35.
  • 5Xie X, Ye Z, Yang D, et al. Effects of combined c-myc and Bmi-1 siRNAs on the growth and chemosensitivity of MG-63 osteosarcoma cells [ J ]. Mol Med Rep,2013,8 ( 1 ) : 168 - 172.
  • 6Song LB,Zeng MS,Liao WT,et al. Bmi-1 is a novel molecular mark- er of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells [ J ]. Cancer Res, 2006,66 (12) :6225 -6232.
  • 7Vonlanthen S, Heighway J, Altermatt H J, et al. The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression [ J ]. Br J Cancer, 2001,84 ( 10 ) :1372 - 1376.
  • 8Wang H, Pan K, Zhang HK, et al. Increased polycomb-group onco- gene Bmi-1 expression correlates with poor prognosis in hepatocellu- lar carcinoma [ J]. J Cancer Res Clin Oncol, 2008,134 (5):535 - 541.
  • 9Alkema MJ,Wiegant J, Raap AK, et al. Characterization and chromo- somal localization of the human proto-oncogene BMI-1 [ J ]. Hum Mol Genet,1993,2(10) :1597 - 1603.
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二级参考文献27

  • 1MENG Xiu-xiang,LIU Wei-hong,LIU Dan-dan,ZHAO Xin-yu,SU Ben-li.Construction of antisense Bmi-1 expression plasmid and its inhibitory effect on K562 cells proliferation[J].Chinese Medical Journal,2005(16):1346-1350. 被引量：9
  • 2Arias AM.Epithelial mesenchymal interactions in cancer and development[J].Cell,2001,105(4):425-431.
  • 3van-Lohuizen M,Frasch M,Wientjens E,et al.Sequence similarity between the mammalian Bmi-l proto-oncogene and the Drosophila regulatory genes Pse and Su(z)2[J].Nature,1991,353(6342):353-355.
  • 4Reinisch C,Kandutsch S,Uthman A,et al.Bim-1:a protein expressed in stem cells,specialized cells and tumors of the gastrointestinal tract[J].Histol Histopathol,2006,21(11):1143-1149.
  • 5van Kemenade FJ,Raaphorst FM,Blokzijl T,et al.Coexpression of Bim-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma[J].Blood,2001,97(12):3896-3901.
  • 6Lindstrom MS,Klangby U,Wiman KG,et al.P14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53[J].Oncogene,2001,20(17):2171-2177.
  • 7Bea S,Tort F,Pinyol M,et al.Bim-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas[J].Cancer Res,2001,61(6):2409-2412.
  • 8Vonlanthen S,Heighway J,Altermatt HJ,et al.The Bim-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression[J].Br J Cancer,2001,84(10):1372-1376.
  • 9Kim JH,Yooh SY,Kim CN,et al.The Bim-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins[J].Cancer Lett,2004,203(2):217-224.
  • 10Feng Y,Song LB,Guo BH,et al.Expression and significance of Bim-1 in breast cancer[J].Ai Zheng,2007,26(2):154-157.

共引文献6

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二级引证文献7

中国临床研究
2014年 第11期

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