无抽搐电休克治疗对精神分裂症的效果及患者认知功能的影响

Effects of modified electroconvulsive therapy on outcome and cognitive function of patients with schizophrenia

目的探讨无抽搐电休克治疗(MECT)对精神分裂症的效果和患者认知功能的影响。方法将符合《国际疾病分类(第10版)》(ICD-10)精神分裂症诊断标准的50例精神分裂症患者作为研究组,进行为期6周的MECT治疗;将50例在性别、年龄、病程、教育程度、诊断上相匹配的单纯药物治疗的患者作为对照组,在治疗前、治疗结束后1天和治疗后2周分别进行阳性与阴性症状量表(PANSS)、威斯康星卡片分类测验(WCST)和韦氏记忆测验(WMS)评定。结果治疗后1天和治疗后2周两组PANSS总评分和各项因子分均较治疗前低,差异有统计学意义(P<0.01)。治疗后1天和治疗后2周研究组WCST的错误应答数和持续性错误数项目得分比治疗前和同期对照组低(P<0.05)。治疗后研究组WMS的再认、图片和联想的项目得分比治疗前和同期对照组均低(P<0.05)。治疗后研究组理解项目得分比治疗前和同期对照组高(P<0.05)。结论合并MECT治疗能快速缓解急性期精神分裂症患者的阳性症状,对记忆可能有部分短暂而可逆的影响,而对执行功能有着不同程度的改善。

Objective To explore the effects of modified electroconvulsive therapy （ MECT） on syndrome and cognitive function of patients with schizophreniac. Methods Selecting 50 cases of patients with schizophreniac treated by MECT as a study group, and other 50 cases with similar gender, age, course, educational level and diagnosis treated only by drugs as a control group. Every patient was assessed by Positive and Negative Syndrome Scale （ PANSS ） , Wisconsin Card Sorting Test （ WCST ） and Wechsler Memory Scale （ WMS） pre-treatment, post-treatment and 2 weeks after the treatment. The results of the two groups were then compared. Results