叶酸辅助治疗对老年H型高血压颈动脉结构和功能及基质金属蛋白酶-9的影响

Impact of folic acid adjuvant treatment on structure and function in elderly H-type hypertensive carotid artery and matrix metalloproteinase-9

目的探讨叶酸辅助治疗对老年H型高血压颈动脉结构、功能及基质金属蛋白酶-9(MMP-9)的影响。方法将270例老年H型高血压患者按照是否予以叶酸辅助治疗分为试验组和常规组,每组各135例,同时选取135例健康体检者为对照组。检测3组受试对象颈动脉结构、功能指标和MMP-9水平。结果与对照组相比,试验组和常规组的颈动脉内膜中层厚度、斑块指数和僵硬度均明显升高,扩张性明显降低,而且试验组的4项指标的改善程度明显优于常规组(P<0.05);此外,试验组和常规组患者的MMP-9和同型半胱氨酸水平也均明显增加,且试验组的上述两项指标水平均明显低于常规组,差异均有统计学意义(P<0.05)。结论叶酸辅助治疗可明显改善老年H型高血压患者颈动脉结构和功能,延缓动脉粥样硬化。

Objective To explore the impact of the adjuvant treatment of folic acid on the structure and func‐tion of elderly H‐type hypertensive carotid artery and matrix metalloproteinase‐9（MMP‐9） .Methods 270 elderly ca‐ses of H‐type hypertension were divided into the experimental group and the conventional group according to whether the folic acid adjuvant therapy was used ,135 cases in each group .At the same time 135 individuals with physical ex‐amination were selected as the control group .The structure and function indicators of carotid artery and MMP‐9 level were detected in three groups .Results Compared with the control group ,the intima‐media thickness（IMT） ,plaque index and stiffness in the experiment group and the conventional group were significantly elevated ,but the expansivity was significantly reduced ,moreover the improvement degree of these four indicators in the experimental group were significantly better than the those in the conventional group（P＆lt;0 .05）;in addition ,the MMP‐9 and Hcy levels in the experimental group and the conventional group were also significantly increased ,moreover the levels of these two in‐dicators in the experimental group were significantly lower than those in the conventional group ,the differences had statistical significance（P＆lt;0 .05） .Conclusion The folic acid adjuvant therapy can significantly improve the carotid artery structure and function in elderly H‐type hypertension ,and delay atherosclerosis .