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酿酒酵母中心代谢网络动力学建模

Kinetic Modeling of Saccharomyces cerevisiae Central Metabolic Network
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摘要 以酿酒酵母中心代谢网络为研究对象进行代谢网络动力学模拟,将酶反应速率方程改写成普适的形式,模拟了以葡萄糖为碳源的一次生长代谢状态,计算得到了代谢网络达到稳态的代谢流分布以及全部代谢物浓度随时间变化的情况,并将模拟得到的代谢流分布与实验结果进行了比较,结果具有一致性. The Saccharomyces cerevisiae central metabolism of exponential growth via generic enzymatic rate equa-tion was simulated. Metabolic fluxes and metabolite concentrations of Saccharomyces cerevisiae central metabolism were calculated over time. The calculated results were in good agreement with the experiments in literature.
作者 陈洁 林保宏
机构地区 上海交通大学系统生物医学研究院 国立台湾科技大学电子工程学系
出处 《信阳师范学院学报（自然科学版）》 CAS 北大核心 2014年第4期483-489,共7页 Journal of Xinyang Normal University(Natural Science Edition)
基金 国家重点基础研究发展计划(973)资助项目(2010CB529200 NFSC91029738)
关键词 代谢网络 动力学建模 酿酒酵母 metabolic network kinetic modeling Saccharomyces cerevisiae
分类号 Q31 [生物学—遗传学]
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参考文献11

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二级参考文献56

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共引文献10

信阳师范学院学报（自然科学版）
2014年 第4期

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