期刊文献+

低位硬膜外麻醉复合全麻对下腹部手术后痛觉过敏的影响 被引量:10

下载PDF
导出
摘要 目的观察全麻下行下腹部手术患者在硬膜外腔注入0.2%罗哌卡因后对其术后痛觉过敏的影响。方法选择全麻下行下腹部开腹手术患者60例,随机分为两组:芬太尼组(F组,N=30)和罗哌卡因组(L组,n=30)。麻醉诱导:均采用丙泊酚血浆靶控浓度3.0~4.0μg/m L,瑞芬太尼血浆靶控浓度3.0~4.0 ng/m L,维库溴铵0.1 mg/kg,肌松满意后行气管插管,用麻醉机控制呼吸。麻醉维持:均采用丙泊酚血浆靶控浓度3.0--5.0μg/m L,瑞芬太尼血浆靶控浓度1.0--5.0 ng/m L,间断静脉推注维库溴铵维持肌松。F组于手术切皮和缝皮前分别静脉注射芬太尼2μg/kg。L组于手术切皮前20 min和关腹前向硬膜外腔分次注入0.2%罗哌卡因10 m L,术中每隔1 h追加0.2%罗哌卡因5 m L。记录入室时(T0)、诱导时(T1)、切皮时(T2)、术中探查时(T3)及关腹时(T4)的收缩压(SBP)、舒张压(DBP)、心率(HR)变化,记录拔管后1 h(T5)、4 h(T6)、12 h(T7)、24 h(T8)的VAS评分、触痛阈及机械痛觉过敏的范围。结果 L组患者SBP和DBP在T2、T3低于F组(P〈0.05),L组患者T5-T8 VAS评分均较F组低(P〈0.05),L组患者三条测定线上触痛阈较F组高,机械痛觉过敏范围较F组窄(P〈0.05)。结论经硬膜外注射低浓度罗哌卡因复合全麻,可减少术中阿片类镇痛药的用量,有效缩小全麻下行下腹部开腹手术痛觉过敏的范围,减轻痛觉过敏的程度。
出处 《广东医学》 CAS CSCD 北大核心 2014年第21期3348-3350,共3页 Guangdong Medical Journal
基金 广西自然科学基金资助项目(编号:2011GXNSFA018222)
  • 相关文献

参考文献13

  • 1俞红丽,于布为.麻醉手术后痛觉过敏的研究进展[J].上海医学,2009,32(6):532-536. 被引量:16
  • 2SIMONNET G, RIVAT C. Opioid - induced hyperalgesia : abnor- mal or normal pain? [J]. Neuroreport, 2003, 14:1 -7.
  • 3ISHIDA R, NIKAI T, HASHIMOTO T, etc. Intravenous infusion of remifentanil induces transient withdrawal hyperalgesia depending on administration uration in rats [ J ]. Anesth Analg, 2012, 114 ( 1 ) : 224 - 229.
  • 4HOOD D D, CURRY R, EISENACH J C. Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin - in- duced hyperalgesia[J]. Anesth Analg, 2003, 97(3) : 810 -815.
  • 5TROSTER A, SITYL R, SINGLER B, et al. Modulation of remifentanil - induced analgesia and postinfusion hyperalgcsia by parecoxib in humans [J].Anesthesiology, 2006, 105 ( 5 ) : 1016 - 1023.
  • 6OBATA H, SAITO S, FUJITA N, et al. Epidural block with mepi- vacaine before surgery reduces long - term post - thoraeotomy pain [J]. CanJAnesth, 1999, 46(12): 1127 -1132.
  • 7路喻清,冯阳阳,史军军,张向东,胡彬.全身麻醉复合硬膜外麻醉对胃癌术后镇痛的影响[J].现代肿瘤医学,2011,19(4):764-766. 被引量:19
  • 8张磊,曾丽,蓝雨雁,等.低浓度罗哌卡因注入硬膜对术后痛觉过敏的影响[J].广东医学,2013,34(11):1714-1715.
  • 9UDELSMANN A, SILVA W A, MORAES A C, et al. Hemody- namic effects of ropivacaine and levobupivacaine intravenous injec- tion in swines[J]. Aeta Cir Bras, 2009, 24(4) : 296 -302.
  • 10DEVOR M, WALL P D, CATALAN N. Systemic lidoeaine si- lences eetopie neuroma and DRG discharge without bloeking nerve eonduetion[Jl. Pain, 1992, 48(2) : 261 -268.

二级参考文献10

  • 1郑跃英,祝胜美.吗啡增强痛觉敏感性机制的研究进展[J].国际麻醉学与复苏杂志,2006,27(5):320-320. 被引量:5
  • 2Kavanagh BP,Katz J,Sandler AN.Pain control after thoracic surgery:A review of current techniques[J].Anesthesiology,1994,81:737.
  • 3Wu CL,Fleisher LA.Outcomes research in regional anesthesia and analgesia[J].Anesth Analg,2000,91:1232.
  • 4Roberts Gregory W.B Pharm,Fshp,et al.Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner[J].Anesth Analg,2005,101:1343-1348.
  • 5Takada M,Fukusaki M,Terao Y,et al.Preadministration of flurbiprofen suppresses prostaglandin production and post operative pain in orthopedic patients undergoing tourniquetinflation[J].Clin Anesth,2007,19(2):97-100.
  • 6Sedinkin AA,Balandin AV,Dimova AD.Results of an openprospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patiens with throat pain[J].Ter Arkh,2005,77(9):74-76.
  • 7Xu Y,Tan Z,Chen J,et al.Intravenous flurbiprofen axetilaccelerates restoration of bowel function after colorectal surgery[J].Can J Anaesth,2008,55:414-422.
  • 8Takada M,Fukusaki M,Terao Y,et al.Preadministration of flurbiprofen suppresses prostaglandin production and post-operative pain in orthopedic patients undergoing tourniquetinflation[J].J Clin Anesth,2007,19:97-100.
  • 9Kaufman E,Epstein JB,Gorsky M,et al.Preemptive analgesia and local anesthesia as a supplement to general anesthesia:a review[J].Spring,2005,52(1):29-38.
  • 10沈锦春,郭海峰,杨建军,段满林,朱四海,徐建国.氟比洛芬酯联合吗啡镇痛对胃癌患者术后吗啡用药量及肠功能恢复的影响[J].临床麻醉学杂志,2009,25(5):383-386. 被引量:38

共引文献54

同被引文献62

引证文献10

二级引证文献55

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部