阿霉素心肌毒性机制研究进展

Research progress of mechanisms on doxorubicin-induced cardiotoxicity

阿霉素属于蒽醌类抗肿瘤药,临床上用于白血病、淋巴瘤、乳腺癌等多种恶性肿瘤的治疗,且作用广谱,效果显著,但其所致心肌毒性不仅限制了其临床使用,也影响了患者的生活质量。因此,探讨阿霉素诱导心肌毒性的作用机制具有重要意义,本文就近年来阿霉素所致心肌毒性的作用机制研究做一综述。

Doxorubicin, an anthraquinones antineoplastic agent, is extensively and effectively used for leukemia, lymphoma, breast cancer and many other malignant tumors in clinical practice. However, doxorubicin-induced cardiotoxicity not only restricts the use of doxorubicin, but also lowers the life quality of patients. It is of great importance to explore the mechanism of doxorubicin-induced cardiotoxicity. We reviewed the possible mechanisms recently studied to better understand doxorubicin-induced cardiotoxicity.