MicroRNA在慢性乙型肝炎中医证候研究中的应用前景

Application prospect of micro RNA in the study of traditional Chinese medicine syndromes of chronic hepatitis B

Micro RNA(mi RNA)是一类非编码的单链小分子RNA,通过和靶基因m RNA碱基配对引导沉默复合体(RNA-induced silence complex,RISC)降解m RNA或抑制m RNA的翻译,从而在转录后水平调控蛋白表达。Mi RNA与慢性乙型肝炎病毒复制、肝细胞增殖和分化、肝细胞癌发生等病理生理过程密切相关。中医药防治慢性乙型肝炎已有悠久的历史,辨证论治是中医治疗慢性乙型肝炎的优势也是特色,对中医证候的深入研究和科学解释是提高整个中医治疗慢性乙型肝炎临床水平的关键。mi RNA调控的整体性、多层次性及复杂性与中医学特点相似,应用于中医药研究领域取得了较为丰硕成果,将mi RNA引入慢性乙型肝炎中医证候研究,建立与证候相关的mi RNA调控网络,寻找特异性证候生物学标志谱,为从转录后水平开展慢性乙型肝炎中医证候客观化研究提供了新的平台与机遇。

MicroRNA （miRNA） is a single-stranded small non-coding RNA molecule, and the target gene mRNA by base pairing guide silencing complex （RNA-induced silence complex, RISC） degradation of mRNA or inhibit translation of mRNA, which functions in post-transcriptional regulation of protein expression. MiRNA is closely correlated with the pathophysiological processes of virus replication in chronic hepatitis B （CHB）, proliferation and differentiation of the hepatic cell, occurrence of hepatocellular carcinoma. Traditional Chinese Medicine （TCM） has a long history in the treatment of CHB, the syndrome differentiation has an advantage and characteristics of TCM in the treatment of CHB. The key of improving the level of TCM in the treatment of CHB is the intensive study and scientific explanation of TCM syndromes. The integrity, multiple-layered and complexity of miRNA regulation are correspond with the TCM characteristics, miRNA has gained delightful achievements used in the TCM research. It will bring miRNA to the CHB study of TCM syndromes, to build the miRNA regulation networks related to TCM syndromes, and find the biomarker spectrum of specific syndromes, which can provide a new platform and oooottunitv for the obiective research of CHB TCM syndromes at the post-transcriptional level.