27例人类免疫缺陷病毒感染ⅡA期患者连续中医药治疗4年T淋巴细胞水平分析

T lymphocyte level analysis of twenty-seven patients with HIV infection ⅡA period treated with TCM for four years

目的:探讨中医药对人类免疫缺陷病毒(HIV)感染ⅡA期患者T淋巴细胞水平的影响。方法:收集云南省2006年8月-2012年5月期间连续应用中医药治疗4年的HIV感染ⅡA期患者27例,对患者治疗前后5个时间点(0、12、24、36、48个月)的T淋巴细胞计数进行观察分析。结果:中医药治疗HIV感染ⅡA期患者CD4+T淋巴细胞计数随时间的变化而降低,从治疗前平均517个/μL降低至疗后439个/μL,下降速度略低于自然下降速度;CD8+T淋巴细胞计数随时间的变化总体呈平稳趋势,CD4+T、CD8+T淋巴细胞计数治疗前后无差异。结论:中医药治疗HIV感染ⅡA期患者可影响CD4+和CD8+T细胞数量,减缓CD4+T淋巴细胞下降速度,维持机体正常的免疫功能,延缓艾滋病病程进展。

Objective： To explore the influence of Chinese medicine on T lymphocyte level analysis of 27 patients with HIV infection ⅡA period. Methods： Twenty-seven patients with HIV infection ⅡA period treated with traditional Chinese medicine （TCM） from 2006 to 2012 in Yunnan province were gathered. T lymphocyte counts were analyzed of patients on 5 time points （0, 12, 24, 36, 48 months） before and after treatment. Results： CD~ T lymphocyte counts of patients treated with TCM were reduced with the change of time, from average 517 cell/μL before therapy to average 439 cell/μL after treatment, but the decline speed was slightly lower than the natural decline speed. CD^8 T lymphocyte counts changes were in the overall stable trend over time. There were no differences between before and after of treatment of CD^＋4 and CD^＋8 T lymphocyte counts. Conclusion： The counts of CD^＋4 and CD^＋8 T in patients with HIV infection ⅡA period could be influenced by TCM treatment, and TCM treatment could maintain the body＇s normal immune function and delay AIDS progress by slowing the descent of CD^＋4 counts.