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他汀类药物预防结直肠癌的系统评价和Meta分析

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摘要 目的:探讨他汀类药物是否可预防结直肠癌的发生。方法计算机检索Cochrane Library、PubMed、EMbase等数据库,并辅以手工和其他检索,收集国内外关于他汀类药物与结直肠癌发生率关系的研究,采用相对危险度(RR)作为统计学指标对入选文献进行综合分析,用RevMan 5.0统计软件进行分析。结果符合要求的文献有28篇,病例对照研究15篇,队列研究6篇,随机对照研究7篇,进行Meta分析,与对照组比较,他汀类药物组结直肠癌发生率较低(RR值为0.93,95%CI为0.91-0.96,P〈0.05)。结论应用他汀类药物可预防结直肠癌,降低其发病风险。
出处 《浙江临床医学》 2014年第11期1777-1778,共2页 Zhejiang Clinical Medical Journal
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