谷氨酰胺在胃肠肿瘤患者术后的应用进展

Application progress of Glutamine in the gastrointestinal cancer patients after operation

谷氨酰胺是一种条件性必需氨基酸，是血浆中含量最高的氨基酸，约占全身游离氨基酸的60％，在正常血浆浓度为0．6～0．9mmol／L。近年来，随着谷氨酰胺在临床营养领域研究的不断深入，已从过去单纯的营养支持治疗逐步转为免疫营养治疗的概念。谷氨酰胺能够改善机体的蛋白质营养水平，保护胃肠道黏膜，提高免疫功能，降低感染发病率，减轻机体炎症反应，降低化疗的不良反应，增强肿瘤对化疗药物的敏感性，促进胃肠肿瘤患者术后恢复，减少手术并发症。本文对谷氨酰胺在胃肠肿瘤患者术后的应用研究方面做一综述。

Glutamine is not only a special nutritional substance but a conditional essential amino acid, which is the most abundant amino acids in plasma, representing about 60% of free amino acids in the body, and it＇s normal plasma concentration is from 0.6 to 0.9 mmol/L. In recent years, with the increasing deepe- ning study of the field of clinical nutrition, the concept of glutamine study has been gradually changed gradu- ally changed it＇s concept from a simple nutritional support to immune nutrition therapy. Glutamine can not only improve the body＇s protein levels of nutrition, protect the gastrointestinal mucosa, but also reduce the in- cidence of infection and the inflammation in the body, improve immune function, reduce side effects of chemotherapy, and at the same time enhance tumor sensitivity to chemotherapy and promote gastrointestinal cancer patients＇ postoperative recovery, reduce surgical complications. This paper aims to review the appli- cation and research of glutamine in the gastrointestinal cancer patients after the operation.