康莱特注射液对晚期非小细胞肺癌化疗患者免疫功能的影响

Regulatory effect of Kanglaite Injection on immune function in patients with non small cell lung cancer treated with chemotherapy

目的探讨晚期非小细胞肺癌患者血中T细胞亚群、CD4+CD25+调解性T细胞(Treg)及免疫球蛋白的改变,观察康莱特注射液(KLT)联合化疗对晚期非小细胞肺癌患者免疫功能的影响。方法将68例晚期非小细胞肺癌患者随机分为2组,对照组应用多西他赛、顺铂联合化疗,不予康莱特及其他提高免疫力的治疗措施;治疗组同时给予康莱特注射液200 m L静点,连用14 d。2组均以21 d为1个周期,2个周期后评价T细胞亚群及免疫球蛋白的变化情况。另选30例健康人作为正常对照组。结果化疗前对照组及治疗组患者T细胞亚群CD3+、CD4+、CD8+比例及CD4+CD25+Treg与正常对照组比较差异有统计学意义(P均<0.05)。化疗后对照组免疫球蛋白、CD3+、CD4+、CD8+、CD4+/CD8+比值及治疗组CD4+CD25+Treg与化疗前比较差异有统计学意义(P均<0.05)。化疗后对照组与治疗组CD3+、CD4+、CD8+及CD4+/CD8+比值、Ig G比较差异有统计学意义(P均<0.05)。结论康莱特注射液可保护晚期非小细胞肺癌患者的免疫功能,降低免疫耐受。

Objective It is to explore the changes of T cell subsets and CD4^＋CD25^＋Treg cells and immunoglobulin in blood of patients with advanced non small cell lung cancer, and to observe the influence of Kanglaite injection （ KLT） combined with chemotherapy on immune function of these patients.Methods 68 cases of patients with advanced non small cell lung cancer were randomly divided into 2 groups, the control group was treated with docetaxel combined with sisplatin, and was not given KLT or other therapy which could improve immune function, and the treatment group was treated with KLT 200 mL by drip intravenous infusion for 14 days on the basis of control group＆#39;s treatment.21 days was one treatment cycles, after two cycles, the changes of T cell subsets and immunoglobulin were observed.30 cases of healthy people were selected as normal control group.Rse ul ts Compared with that before chemotherapy in normal control group, the differences in the levels of T cell subsets CD3^ ＋, CD4 ^＋, CD8^ ＋, CD4^ ＋/CD^8 ＋and the levels of CD4^＋CD 25 ^＋Treg cell were significant in treatment group and control group （P all〈0.05）.After chemotherapy the differences in immunoglobulin and T cell subsets of CD3^ ＋, CD4^＋, CD8 ^＋, CD4 ^＋/CD8 ^＋in control group and CD4^＋CD25^＋Treg in treatment group after treatment were significant （ P all〈0. 05） .There were significant differences in CD3^ ＋, CD4 ^＋, CD8^ ＋, CD4 ^＋/CD8 ^＋and IgG between control group and treatment group after chemotherapy（P〈0.05）.Conclusion Kanglaite injection can protect immune function in patients with advanced non small cell lung cancer and reduce the immune tolerance.