他巴唑片治疗甲状腺功能亢进的临床疗效观察

CLINICAL EFFICACY OF METHIMAZOLE TABLETS IN THE TREATMENT OF HYPERTHYROIDISM

目的探究并分析他巴唑片治疗甲状腺功能亢进的临床疗效。方法选取该院2012年1月—2013年12月收治的100例甲状腺功能亢进患者,将其作为临床研究对象,按照随机数表法将其随机分为观察组和对照组,每组各50例。其中观察组患者采取大剂量他巴唑片治疗,对照组患者采取小剂量他巴唑片治疗。观察并比较二组患者治疗后的疗效、不良反应情况,检测治疗前后的FT3、FT4、TSH水平,并进行比较。结果观察组患者治疗后总有效率为90%,明显高于对照组(68%),组间比较差异有统计学意义(P<0.05);治疗后二组患者FT3、FT4水平较治疗前明显降低,观察组治疗后FT3、FT4水平分别为(8.1±1.2)μmol/L、(18.2±4.6)μmol/L,均较对照组低,组间比较差异有统计学意义(P<0.05);二组患者治疗后TSH水平较治疗前差异无统计学意义(P>0.05),治疗后组间TSH水平比较差异无统计学意义(P>0.05);观察组患者治疗后不良反应的总发生率为32%,明显高于对照组(10%),差异具有统计学意义(P<0.05)。结论服用大剂量他巴唑治疗甲状腺功能亢进的临床疗效优于小剂量他巴唑,但大剂量他巴唑治疗后的不良反应较小剂量多,故临床上应根据患者病情选择合适剂量他巴唑治疗。

Objective To explore and analyze the clinical efficacy of hyperthyroidism methimazole tablets in the treatment of thyroid.Methods One hundred patients as clinical research subjects in Dafeng Third People＇s Hospital from January 2012 to December 2013 were treated by hyperthyroidism ethimazole,and were randomly divided into observation group and control group according to a random number table,50 cases in each group.Observation group was given large doses of methimazole tablets and control group had taken a small dose of methimazole tablets therapy.The treatment efficacy and adverse reactions of two groups,FT3,FT4,TSH levels before and after treatment were observed and compared.Results The total effective rate of observation group was 90%,significantly higher than control group（68%）,there was significant differences between the two groups（P0.05）.After treatment,FT3,FT4 levels were significant reduced than that of before treatment.FT3,FT4 of observation group levels were（8.1±1.2）μmol/L,（18.2±4.6）μmol/L,lower than control group,there was significant differences（P〈0.05）between the two groups.TSH level of two groups was no significant difference before and after treatment（P〉0.05）,as well as there was no significant difference（P〉0.05）between groups after treatment.Overall the incidence of adverse reactions of observation group was 32% after treatment,significantly higher than that in the control group（10%）,P〈0.05.Conclusions The clinical efficacy of large doses of methimazole in treatment of hyperthyroidism is better than small doses,but adverse reactions after high-dose treatment with methimazole are higher than smaller doses.It should choose the appropriate dose base on the patient＇s condition.