Survivin在肾细胞癌患者手术前后外周血中的变化

EXPRESSION OF SURVIVIN IN PERIPHERAL BLOOD OF RENAL CELL CARCINOMA BEFORE/AFTER OPERATION

目的探讨Survivin在肾细胞癌(renal cell carcinoma,RCC)患者手术前后外周血液中的表达变化及其意义。方法采用双抗体夹心酶联免疫吸附法(ELISA)检测30例RCC行肾癌根治术患者和10例非肿瘤原因切肾患者术前1d、术后第七天外周血中Survivin含量表达变化情况。结果 10例非肿瘤原因切肾患者术前1d、术后第七天外周血中Survivin的含量分别为(10.90±14.69)pg/ml、(5.00±10.58)pg/ml;30例RCC患者术前1d、术后第七天外周血中Survivin的含量分别为(125.80±49.28)pg/ml、(31.53±23.70)pg/ml。对照组术前术后相比,差异无统计学意义。RCC组术前术后相比,术后明显下降,差异有统计学意义。对照组与RCC组相比,术前术后差异均有统计学意义。结论肾细胞癌根治术后,Survivin在外周血中含量随之明显下降,进一步说明了Survivin与RCC的预后有一定的关系。测定外周血中Survivin含量可作为监测肿瘤发生和预后的一个重要指标,将有助于肿瘤的早期诊断和预后的评估。

Objective To study the expression and significance of survivin in peripheral blood of renal cell carcinoma（RCC）before/after operation.Methods The content of survivin in peripheral blood before/after operation of 30 patients with RCC and 10 nontumorous patients were detected by enzyme linked immunosorbent assay（ELISA）.Results The content of survivin in peripheral blood of 30 cases of RCC was（125.80±49.28）pg/ml one day postoperatively,while the content one week postoperatively was（31.53±23.70）pg/ml.Compared with the content of preoperatively one day,the content of postoperatively was in decreasing trend.There was no statistically significant difference in Pre/Post operation of 10 nontumorous patients（P〈0.05）.Conclusions The expression of suvrivin in peripheral blood of RCC patients is significantly decreasing after operation.It suggests that survivin is tightly related with the tumor＇s progress.Therefore,the expression of suvrivin in peripheral blood of RCC patients can lay an important role in diagnose and the forecasting of tumor recurrence after operation of RCC.