IL-6与社区获得性肺炎严重程度及预后的相关性

Correlation between IL-6 level and severity and prognosis of community-acquired pneumonia

目的研究血清中白细胞介素-6(IL-6)表达水平与社区获得性肺炎严重程度及预后的相关性。方法选择58例PSI评分Ⅲ-Ⅴ类的社区获得性肺炎患者为入组病例,通过酶联免疫吸附试验法(ELISA)检测入组患者入院第1天清晨空腹血清中IL-6的表达水平,分析IL-6血清浓度与PSI评分的相关性,同时对死亡组和存活组IL-6血清浓度进行比较。结果IL-6在PSI评分Ⅴ类患者中血清含量最高,Ⅳ类次之,Ⅲ类最低,两两比较,差异均具有统计学意义(P<0.05),并且死亡组IL-6血清浓度明显高于存活组(P<0.05)。结论 IL-6在肺炎患者血清中的浓度升高,并随PSI评分的增高而增高,提示其与肺炎病情的严重程度及预后具有相关性。

Objective To explore the correlation between interleukin 6 （IL-6） and severity and prognosis of community-acquired pneumonia.Methods Totally 58 cases of PSI Ⅲ-Ⅴ were enrolled in the research.The serum expression of IL-6 in these patients were measured by enzyme-linked immunosorbent assay（ELISA）.The correlation between serum concentration of IL-6 and pneumonia severity index（PSI） score was analyzed.Serum concentration of IL-6 was compared between death group and survival group.Results Serum expression of IL-6 was the highest in PSI Ⅴ patients,and the lowest in PSI Ⅲ patients.The difference was statistically significant between patients with PSI Ⅲ-Ⅴ （P ＜ 0.05）.Serum concentration of IL-6 was significantly higher in death group than that in survival group（P ＜ 0.05）.Conclusion Serum expression of IL-6 in patients with community-acquired pneumonia may be correlated with the severity and prognosis of pneumonia.